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Journal of Clinical Microbiology, December 2000, p. 4394-4401, Vol. 38, No. 12
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular Epidemiology of Human Group A Rotavirus Infections in the United Kingdom between 1995 and 1998

Miren Iturriza-Gómara,1 Jon Green,2 David W. G. Brown,2 Mary Ramsay,3 Ulrich Desselberger,1 and James J. Gray1,*

Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge,-CB2 2QW,1 and Enteric and Respiratory Virus Laboratory, Virus Reference Division, Central Public Health Laboratory,2 and Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service,3 Colindale, London NW9 5HT, United Kingdom

Received 9 May 2000/Returned for modification 24 July 2000/Accepted 5 September 2000

The G and P types of 2,912 rotavirus-positive fecal specimens collected from eight geographical areas of the United Kingdom between 1995 and 1998 were determined by reverse transcription-PCR. Although 15 different G-P combinations were identified, G1P[8], G2P[4], G3P[8], and G4P[8] strains constituted 95% of all the rotaviruses typed. Other genotypes included G9P[6] and G9P[8], which were first identified in the United Kingdom in 1995, or other uncommon G and/or P types of strains that may have had an animal origin. Unusual combinations of G1 or G4 with P[4] and G2 with P[8] which may have arisen by reassortment between human strains were also identified. G1P[8] was the genotype most frequently found (57 to 87%) in each season, followed by G2P[4] in the 1995-1996 (18%) and 1997-1998 (16%) seasons, although the incidence of infection with this virus decreased significantly to 2% during the 1996-1997 season. Significant differences were seen in the distributions of G1P[8], G2P[4], and G9P[8] strains between children and adults, in the temporal distributions of G4P[8] and G9P[8] strains within a season, and in the geographical distributions of each of the four most common genotypes from one season to the next.

* Corresponding author. Mailing address: Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QW, United Kingdom. Phone: 44-1223-257028. Fax: 44-1223-242775. E-mail: jg2{at}mole.bio.cam.ac.uk.

Journal of Clinical Microbiology, December 2000, p. 4394-4401, Vol. 38, No. 12
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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