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Journal of Clinical Microbiology, March 2000, p. 1283-1285, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Report of the First Human Case of Lobomycosis in the United States

Robert A. Burns,1 J. Stephen Roy,2 Cavan Woods,1 Arvind A. Padhye,3,* and David W. Warnock3

North Georgia Surgical Associates, Dalton, Georgia 307221; Dianon Systems Inc., Stratford, Connecticut 066152; and Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303333

Received 30 August 1999/Returned for modification 27 October 1999/Accepted 27 December 1999

We describe the first human case of lobomycosis caused by Lacazia loboi in a 42-year-old white male resident of Georgia. The patient had traveled to Venezuela 7 years earlier, where he had planned to rappel down Angel Falls in Canaima. Although he never actually rappelled the falls, he did walk under the falls at least three times, exposing himself to the high water pressures of the falls. He noticed a small pustule with surrounding erythema developing on the skin of his right chest wall. The lesion gradually increased in size and had an appearance of a keloid. For cosmetic reasons, the patient sought medical treatment to remove the lesion. After an uncomplicated excision of the lesion, the patient recovered completely. The excised tissue was fixed in formalin for pathologic examination. Tissue sections stained by hematoxylin and eosin, periodic acid-Schiff stain, and Gomori methenamine silver stain procedures showed numerous histiocytes, multinucleated giant cells, and numerous globose or subglobose, lemon-shaped cells producing multiple blastoconidia connected by narrow tube-like connectors and catenate chains of various lengths characteristic of L. loboi.

* Corresponding author. Mailing address: Mycotic Diseases Branch, Mail Stop G-11, Centers for Disease Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-3749. Fax: (404) 639-3546. E-mail: aap1{at}cdc.gov.

Journal of Clinical Microbiology, March 2000, p. 1283-1285, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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