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Journal of Clinical Microbiology, April 2000, p. 1449-1452, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Analysis of Plasmid and Chromosomal DNA of Multidrug-Resistant Salmonella enterica Serovar Typhi from Asia

S. Mirza,1,2 S. Kariuki,1,3 K. Z. Mamun,1,4 N. J. Beeching,5 and C. A. Hart1,*

Departments of Medical Microbiology and Genitourinary Medicine1 and School of Tropical Medicine,5 University of Liverpool, Liverpool L69 3GA, United Kingdom; Armed Forces Institute of Pathology, Rawalpindi, Pakistan2; Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya3; and Dhaka Medical College, Dhaka, Bangladesh4

Received 23 August 1999/Returned for modification 26 November 1999/Accepted 23 January 2000

Molecular analysis of chromosomal DNA from 193 multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates from 1990 to 1995 from Pakistan, Kuwait, Malaysia, Bangladesh, and India produced a total of five major different pulsed-field gel electrophoresis (PFGE) patterns. Even within a particular country MDR S. enterica serovar Typhi DNA was found to be in different PFGE groups. Similar self-transferable 98-MDa plasmids belonging to either incompatibility group incHI1 or incHI1/FIIA were implicated in the MDR phenotype in S. enterica serovar Typhi isolates from all the locations except Quetta, Pakistan, where the majority were of incFIA. A total of five different PFGE genotypes with six different plasmids, based on incompatibility and restriction endonuclease analysis groups, were found among these MDR S. enterica serovar Typhi isolates.

* Corresponding author. Mailing address: Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, P.O. Box 147, Liverpool L69 3GA, United Kingdom. Phone: 0151-706 4381. Fax: 0151-706 5805. E-mail: cahmm{at}liv.ac.uk.

Journal of Clinical Microbiology, April 2000, p. 1449-1452, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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