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Journal of Clinical Microbiology, April 2000, p. 1648-1650, Vol. 38, No. 4
Division of Infectious Diseases, Department
of Medicine, New York Medical College, Valhalla, New York
10595,1 and New York College of
Osteopathic Medicine Microbiology and Immunodiagnostic Laboratory of
the New York Institute of Technology, Old Westbury, New York
115682
Received 5 November 1999/Returned for modification 20 December
1999/Accepted 2 February 2000
In an initial experiment, culture-grown Borrelia
burgdorferi was added to freshly collected uninfected human
blood. This in vitro study demonstrated that more spirochetes were
distributed into the plasma than into the serum fraction. In a
subsequent clinical study, B. burgdorferi was recovered
from plasma cultures of approximately 50% of 42 patients with early
Lyme disease associated with erythema migrans. The rate of recovery
from plasma cultures was significantly greater than that from serum
cultures (P < 0.001).
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Comparison of the Yields of Blood Cultures Using
Serum or Plasma from Patients with Early Lyme Disease
*
Corresponding author. Mailing address: Division of
Infectious Diseases, Room 209SE, Macy Pavilion, Westchester Medical
Center, Valhalla, NY 10595. Phone: (914) 493-8865. Fax: (914) 493-7289. E-mail: Gary_Wormser{at}NYMC.EDU.
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