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Journal of Clinical Microbiology, April 2000, p. 1661-1663, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Relevance of Commercial Diagnostic Tests to Detection of Enteric Adenovirus Infections in South Africa

P. L. Moore,1,* A. D. Steele,2 and J. J. Alexander1

Department of Microbiology, University of the Witwatersrand, Johannesburg,1 and MRC/Medunsa Diarrhoeal Pathogens Research Unit, Department of Virology, Medical University of Southern Africa, Pretoria,2 South Africa

Received 31 August 1999/Returned for modification 17 November 1999/Accepted 27 January 2000

The prevalence of enteric adenoviruses detected by an in-house enzyme-linked immunosorbent assay (the RIVM-ELISA) ranged from 13 to 38%, and subgroup F adenoviruses comprised 86%. All subgroup F adenoviruses reacted with both RIVM anti-adenovirus type 40 (Ad40) and anti-adenovirus type 41 (Ad41) monoclonal antibodies but were not detected by Adenoclone Type 40/41 enzyme immunoassay (EIA). The correlation between the Biotrin EIA and RIVM-ELISA results was low (26%). Immunospecific tests suggest that a significant proportion of enteric adenoviruses, possibly comprising previously unidentified or emerging types, are not detected by commercial diagnostic tests in South Africa.

* Corresponding author. Present address: Centre for Hepatology, Department of Medicine, Upper Third Floor, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St., London NW3 2PF, United Kingdom. Phone: 44 171 472 6155. Fax: 44 171 433 2852. E-mail: p.moore{at}rfc.ucl.ac.uk.

Journal of Clinical Microbiology, April 2000, p. 1661-1663, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2000 by the American Society for Microbiology. All rights reserved.