This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Limaye, A. P.
Right arrow Articles by Fritsche, T. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Limaye, A. P.
Right arrow Articles by Fritsche, T. R.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 2000, p. 1696-1697, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Pseudomembranous Colitis Caused by a Toxin Aminus B+ Strain of Clostridium difficile

Ajit P. Limaye,* David K. Turgeon, Brad T. Cookson, and Thomas R. Fritsche

Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195

Received 29 November 1999/Returned for modification 22 January 2000/Accepted 25 January 2000

We report a case of severe pseudomembranous colitis due to a toxin A- B+ strain of Clostridium difficile in an immunosuppressed patient and discuss the implications for diagnostic testing in suspected C. difficile-associated diarrhea.

* Corresponding author. Mailing address: University of Washington Medical Center, Department of Laboratory Medicine, Box 357110, 1959 N.E. Pacific St., Seattle, WA 98195-7110. Phone: (206) 598-6131. Fax: (206) 598-6189. E-mail: limaye{at}u.washington.edu.

Journal of Clinical Microbiology, April 2000, p. 1696-1697, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Shin, B.-M., Kuak, E. Y., Yoo, H. M., Kim, E. C., Lee, K., Kang, J.-O., Whang, D. H., Shin, J.-H. (2008). Multicentre study of the prevalence of toxigenic Clostridium difficile in Korea: results of a retrospective study 2000-2005. J Med Microbiol 57: 697-701 [Abstract] [Full Text]  
  • Chae, S., Eckmann, L., Miyamoto, Y., Pothoulakis, C., Karin, M., Kagnoff, M. F. (2006). Epithelial Cell I{kappa}B-Kinase beta Has an Important Protective Role in Clostridium difficile Toxin A-Induced Mucosal Injury. J. Immunol. 177: 1214-1220 [Abstract] [Full Text]  
  • Ticehurst, J. R., Aird, D. Z., Dam, L. M., Borek, A. P., Hargrove, J. T., Carroll, K. C. (2006). Effective Detection of Toxigenic Clostridium difficile by a Two-Step Algorithm Including Tests for Antigen and Cytotoxin.. J. Clin. Microbiol. 44: 1145-1149 [Abstract] [Full Text]  
  • Carneiro, B. A., Fujii, J., Brito, G. A. C., Alcantara, C., Oria, R. B., Lima, A. A. M., Obrig, T., Guerrant, R. L. (2006). Caspase and Bid Involvement in Clostridium difficile Toxin A-Induced Apoptosis and Modulation of Toxin A Effects by Glutamine and Alanyl-Glutamine In Vivo and In Vitro. Infect. Immun. 74: 81-87 [Abstract] [Full Text]  
  • Kato, H., Yokoyama, T., Kato, H., Arakawa, Y. (2005). Rapid and Simple Method for Detecting the Toxin B Gene of Clostridium difficile in Stool Specimens by Loop-Mediated Isothermal Amplification. J. Clin. Microbiol. 43: 6108-6112 [Abstract] [Full Text]  
  • Voth, D. E., Ballard, J. D. (2005). Clostridium difficile Toxins: Mechanism of Action and Role in Disease. Clin. Microbiol. Rev. 18: 247-263 [Abstract] [Full Text]  
  • Pituch, H., Kreft, D., Obuch-Woszczatynski, P., Wultanska, D., Meisel-Mikolajczyk, F., Luczak, M., van Belkum, A. (2005). Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea. J. Clin. Microbiol. 43: 472-475 [Abstract] [Full Text]  
  • Lemee, L., Dhalluin, A., Testelin, S., Mattrat, M.-A., Maillard, K., Lemeland, J.-F., Pons, J.-L. (2004). Multiplex PCR Targeting tpi (Triose Phosphate Isomerase), tcdA (Toxin A), and tcdB (Toxin B) Genes for Toxigenic Culture of Clostridium difficile. J. Clin. Microbiol. 42: 5710-5714 [Abstract] [Full Text]  
  • Lemee, L., Dhalluin, A., Pestel-Caron, M., Lemeland, J.-F., Pons, J.-L. (2004). Multilocus Sequence Typing Analysis of Human and Animal Clostridium difficile Isolates of Various Toxigenic Types. J. Clin. Microbiol. 42: 2609-2617 [Abstract] [Full Text]  
  • van den Berg, R. J., Claas, E. C. J., Oyib, D. H., Klaassen, C. H. W., Dijkshoorn, L., Brazier, J. S., Kuijper, E. J. (2004). Characterization of Toxin A-Negative, Toxin B-Positive Clostridium difficile Isolates from Outbreaks in Different Countries by Amplified Fragment Length Polymorphism and PCR Ribotyping. J. Clin. Microbiol. 42: 1035-1041 [Abstract] [Full Text]  
  • Blake, J. E., Mitsikosta, F., Metcalfe, M. A. (2004). Immunological detection and cytotoxic properties of toxins from toxin A-positive, toxin B-positive Clostridium difficile variants. J Med Microbiol 53: 197-205 [Abstract] [Full Text]  
  • Pituch, H., van Belkum, A., van den Braak, N., Obuch-Woszczatynski, P., Verbrugh, H., Meisel-Mikolajczyk, F., Luczak, M. (2003). Recent Emergence of an Epidemic Clindamycin-Resistant Clone of Clostridium difficile among Polish Patients with C. difficile-Associated Diarrhea. J. Clin. Microbiol. 41: 4184-4187 [Abstract] [Full Text]  
  • Johnson, S., Sambol, S. P., Brazier, J. S., Delmee, M., Avesani, V., Merrigan, M. M., Gerding, D. N. (2003). International Typing Study of Toxin A-Negative, Toxin B-Positive Clostridium difficile Variants. J. Clin. Microbiol. 41: 1543-1547 [Abstract] [Full Text]  
  • Aboudola, S., Kotloff, K. L., Kyne, L., Warny, M., Kelly, E. C., Sougioultzis, S., Giannasca, P. J., Monath, T. P., Kelly, C. P. (2003). Clostridium difficile Vaccine and Serum Immunoglobulin G Antibody Response to Toxin A. Infect. Immun. 71: 1608-1610 [Abstract] [Full Text]  
  • Rupnik, M., Kato, N., Grabnar, M., Kato, H. (2003). New Types of Toxin A-Negative, Toxin B-Positive Strains among Clostridium difficile Isolates from Asia. J. Clin. Microbiol. 41: 1118-1125 [Abstract] [Full Text]  
  • Chaves-Olarte, E., Freer, E., Parra, A., Guzman-Verri, C., Moreno, E., Thelestam, M. (2003). R-Ras Glucosylation and Transient RhoA Activation Determine the Cytopathic Effect Produced by Toxin B Variants from Toxin A-negative Strains of Clostridium difficile. J. Biol. Chem. 278: 7956-7963 [Abstract] [Full Text]  
  • Wilkins, T. D., Lyerly, D. M. (2003). Clostridium difficile Testing: after 20 Years, Still Challenging. J. Clin. Microbiol. 41: 531-534 [Full Text]  
  • Barbut, F., Lalande, V., Burghoffer, B., Thien, H. V., Grimprel, E., Petit, J.-C. (2002). Prevalence and Genetic Characterization of Toxin A Variant Strains of Clostridium difficile among Adults and Children with Diarrhea in France. J. Clin. Microbiol. 40: 2079-2083 [Abstract] [Full Text]  
  • Johnson, S., Kent, S. A., O'Leary, K. J., Merrigan, M. M., Sambol, S. P., Peterson, L. R., Gerding, D. N. (2001). Fatal Pseudomembranous Colitis Associated with a Variant Clostridium difficile Strain Not Detected by Toxin A Immunoassay. ANN INTERN MED 135: 434-438 [Abstract] [Full Text]  
  • Kurtz, C. B., Cannon, E. P., Brezzani, A., Pitruzzello, M., Dinardo, C., Rinard, E., Acheson, D. W. K., Fitzpatrick, R., Kelly, P., Shackett, K., Papoulis, A. T., Goddard, P. J., Barker, R. H. Jr., Palace, G. P., Klinger, J. D. (2001). GT160-246, a Toxin Binding Polymer for Treatment of Clostridium difficile Colitis. Antimicrob. Agents Chemother. 45: 2340-2347 [Abstract] [Full Text]  
  • O'Connor, D., Hynes, P., Cormican, M., Collins, E., Corbett-Feeney, G., Cassidy, M. (2001). Evaluation of Methods for Detection of Toxins in Specimens of Feces Submitted for Diagnosis of Clostridium difficile- Associated Diarrhea. J. Clin. Microbiol. 39: 2846-2849 [Abstract] [Full Text]  
  • Lozniewski, A., Rabaud, C., Dotto, E., Weber, M., Mory, F. (2001). Laboratory Diagnosis of Clostridium difficile-Associated Diarrhea and Colitis: Usefulness of Premier Cytoclone A+B Enzyme Immunoassay for Combined Detection of Stool Toxins and Toxigenic C. difficile Strains. J. Clin. Microbiol. 39: 1996-1998 [Abstract] [Full Text]  
  • Kato, H., Kato, N., Watanabe, K., Yamamoto, T., Suzuki, K., Ishigo, S., Kunihiro, S., Nakamura, I., Killgore, G. E., Nakamura, S. (2001). Analysis of Clostridium difficile Isolates from Nosocomial Outbreaks at Three Hospitals in Diverse Areas of Japan. J. Clin. Microbiol. 39: 1391-1395 [Abstract] [Full Text]  
  • Mylonakis, E., Ryan, E. T., Calderwood, S. B. (2001). Clostridium difficile-Associated Diarrhea: A Review. Arch Intern Med 161: 525-533 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»