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Journal of Clinical Microbiology, May 2000, p. 1971-1973, Vol. 38, No. 5
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Evidence from a Nine-Year Birth Cohort Study in Japan of Transmission Pathways of Helicobacter pylori Infection

Hoda M. Malaty,1,* Toshiko Kumagai,2 Eiji Tanaka,3 Hiroyoshi Ota,2 Kendo Kiyosawa,3 David Y. Graham,1,4 and Tsutomu Katsuyama2

Department of Medicine1 and Division of Molecular Virology,4 Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, and Department of Laboratory Medicine2 and Second Department of Internal Medicine,3 Shinshu University School of Medicine, Matsumoto, Japan

Received 7 December 1999/Returned for modification 22 January 2000/Accepted 15 February 2000

We examined the longitudinal changes of Helicobacter pylori infection within 46 families with children and 48 couples without children living in Japan. The study cohort was monitored from 1986 to 1994. H. pylori status was assessed by the presence of anti-H. pylori immunoglobulin G antibodies. At study entry, H. pylori prevalence in children with positive mothers was 23% versus 5% in children with negative mothers (odds ratio = 5.3; 95% confidence interval = 0.6 to 42.8). Seroconversion (rate of 1.5%/year) was evident only among children living with positive mothers and did not differ among adults living with or without children. These data strongly support the cluster phenomenon of H. pylori infection among families, the key role of the infected mothers in the transmission within families, and the importance of adult-child transmission and not vice versa.

* Corresponding author. Mailing address: Veterans Affair Medical Center (111D), 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 795-0232. Fax: (713) 790-1040. E-mail: Hmalaty{at}bcm.tmc.edu.

Journal of Clinical Microbiology, May 2000, p. 1971-1973, Vol. 38, No. 5
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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