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Journal of Clinical Microbiology, May 2000, p. 2015-2017, Vol. 38, No. 5
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Infective Endocarditis Complicated with Progressive Heart Failure due to beta -Lactamase-Producing Cardiobacterium hominis

Po-Liang Lu,1 Po-Ren Hsueh,1,2 Chien-Ching Hung,1 Lee-Jene Teng,3 Tsrang-Neng Jang,4 and Kwen-Tay Luh1,2,*

Departments of Internal Medicine1 and Laboratory Medicine,2 National Taiwan University Hospital, School of Medical Technology, National Taiwan University College of Medicine,3 and Department of Medicine, Shin Kong Wu Ho-Su Memorial Hospital,4 Taipei, Taiwan

Received 30 December 1999/Returned for modification 15 February 2000/Accepted 28 February 2000

We describe a 66-year-old woman with infective endocarditis due to Cardiobacterium hominis whose condition, complicated by severe aortic regurgitation and congestive heart failure, necessitated aortic valve replacement despite treatment with ceftriaxone followed by ciprofloxacin. The blood isolate of C. hominis produced beta -lactamase and exhibited high-level resistance to penicillin (MIC, >= 256 µg/ml) and reduced susceptibility to vancomycin (MIC, 8 µg/ml).

* Corresponding author. Mailing address: Department of Laboratory Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Rd., Taipei, Taiwan. Phone: 886-2-23562149. Fax: 886-2-23224263. E-mail: luhkt{at}ha.mc.ntu.edu.tw.

Journal of Clinical Microbiology, May 2000, p. 2015-2017, Vol. 38, No. 5
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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