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Journal of Clinical Microbiology, June 2000, p. 2103-2107, Vol. 38, No. 6
Department of Infectious Diseases and Medical
Microbiology, University of Lund, Lund, Sweden1;
Respiratory and Systemic Infection Laboratory, Central Public
Health Laboratory, London, United Kingdom2; and
Department of Medical Microbiology, Tehran University
of Medical Sciences & Health Services, Tehran,
Iran3
Received 14 January 2000/Returned for modification 11 March
2000/Accepted 14 March 2000
Streptococcus pyogenes, a major human pathogen, is
still considered susceptible to beta-lactams, but for other relevant
antibiotics, highly variable resistance rates have been reported. Since
no data were available from Iran, we tested 1,335 throat isolates from
two different regions of the country for their antibiotic susceptibilities and, for comparison, a collection of 80 strains isolated from 1989 to 1991. Erythromycin resistance was uncommon (0.6%), whereas an overall high rate of tetracycline resistance was
found, increasing between 1989-1991 and 1995-1997 from 23 to 42%.
The tetracycline-resistant strains belonged to more than 10 different T
types, the majority being types 4, 11, and B3264. By conventional M
typing of 406 tetracycline-resistant isolates, more than 20 different M
types were found. Approximately 50% of the strains were nontypeable by
T agglutination as well as serological M typing; however, by genotyping
by a combined PCR-capture-enzyme-linked immunosorbent assay, many of
these strains were successfully emm typed. We conclude that
the high rate of tetracycline resistance among Iranian S. pyogenes isolates is due to multiclonal dissemination of
resistance within the streptococcal population rather than epidemic
spread of single clones.
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
High Rate of Tetracycline Resistance in
Streptococcus pyogenes in Iran: an Epidemiological
Study
*
Corresponding author. Mailing address: Department
of Medical Microbiology, Sölvegatan 23, S-22362 Lund,
Sweden. Phone: 46-46173284. Fax: 46-46135936. E-mail:
claes.schalen{at}mmb.lu.se.
Journal of Clinical Microbiology, June 2000, p. 2103-2107, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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