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Journal of Clinical Microbiology, July 2000, p. 2696-2700, Vol. 38, No. 7
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Recognition of Enteropathogenic Escherichia coli Virulence Determinants by Human Colostrum and Serum Antibodies

Aurora Parissi-Crivelli,1 Joaquín M. Parissi-Crivelli,2 and Jorge A. Girón1,*

Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Autónoma Universidad de Puebla, Puebla,1 and Hospital de Subzona Manuel A. Camacho, Martínez de la Torre, Veracruz,2 Mexico

Received 9 February 2000/Returned for modification 28 March 2000/Accepted 2 May 2000

Human colostra and sera collected from Mexican mothers and their children at birth and 6 months thereafter were studied for the presence of antibodies against the bundle-forming pilus and several chromosomal virulence gene products (intimin and secreted proteins EspA and EspB) of enteropathogenic Escherichia coli (EPEC). Among 21 colostrum samples studied, 76, 71.5, 57, and 47% of them contained immunoglobulin A (IgA) antibodies against EspA, intimin, EspB, and BfpA, respectively. Interestingly, there was a difference in IgG response to EPEC antigens between the sera from neonates and sera from the same children 6 months later. While the number of neonates reacting to Esps and intimin diminished when they reached 6 months of age, those reacting with BfpA increased from 9 to 71%. Intimin from an enterohemorrhagic E. coli strain was also recognized by most of the samples reacting with EPEC intimin. These data suggest that Bfp and Esps elicit an antibody response during the early days of life of neonates and support the value of breast-feeding in areas of the world where bacterial diarrheal infections are endemic.

* Corresponding author. Mailing address: Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Edificio 76, 3r Piso, 14 Sur Ave. San Claudio, Ciudad Universitaria, C. P. 72570, Puebla, Puebla, Mexico. Phone: (52-22) 33 20 10. Fax: (52-22) 44 45 18. E-mail: jgiron{at}siu.buap.mx.

Journal of Clinical Microbiology, July 2000, p. 2696-2700, Vol. 38, No. 7
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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