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Journal of Clinical Microbiology, July 2000, p. 2750-2752, Vol. 38, No. 7
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparison of Polymorphism of Thymidine Kinase Gene and Restriction Fragment Length Polymorphism of Genomic DNA in Herpes Simplex Virus Type 1

Masayoshi Nagamine,1,2 Tatsuo Suzutani,2,* Masayuki Saijo,3 Kozaburo Hayashi,4 and Masanobu Azuma2

Departments of Otolaryngology1 and Microbiology,2 Asahikawa Medical College, Asahikawa, 078-8510; Special Pathogens Laboratory, National Institute of Infectious Diseases, Tokyo, 208-0011,3 and Public Health Research Institute, Kobe, 650-0017,4 Japan

Received 11 October 2000/Returned for modification 31 January 2000/Accepted 25 April 2000

The polymorphism of the thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1) was analyzed and was compared with the restriction fragment length polymorphism (RFLP) of the whole genome to evaluate the relative efficiency of the TK gene as a potential probe for identification and discrimination of HSV-1. The effectiveness of using the polymorphism of the TK gene in classifying HSV-1 strains was comparable to that of RFLP analysis of 66 sites, suggesting that TK gene sequencing may have important applications in epidemiological studies of HSV-1.

* Corresponding author. Mailing address: Department of Microbiology, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. Phone: 81-166-68-2393. Fax: 81-166-68-2399. E-mail: suzutani{at}asahikawa-med.ac.jp.

Journal of Clinical Microbiology, July 2000, p. 2750-2752, Vol. 38, No. 7
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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Copyright © 2000 by the American Society for Microbiology. All rights reserved.