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Journal of Clinical Microbiology, July 2000, p. 2772-2773, Vol. 38, No. 7
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Survey for the Presence and Distribution of Human Herpesvirus 8 in Healthy Brain

Paul K. S. Chan,1,* Ho-Keung Ng,2 Jo L. K. Cheung,1 and Augustine F. Cheng1

Department of Microbiology1 and Department of Anatomical and Cellular Pathology,2 The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China

Received 6 March 2000/Returned for modification 27 March 2000/Accepted 28 April 2000

Brain tissues from both sides of the cerebellum and frontal, temporal, parietal, and occipital lobes were collected postmortem from 30 patients for human herpesvirus 8 (HHV-8) detection by PCR. Overall, 42 of 300 (14.0%) samples were positive, with similar rates for each position. Nineteen patients (63.3%) were positive and showed a significant increase in positivity with age (P = 0.007). The results indicate a neuroinvasive and neuropersistent potential of HHV-8.

* Corresponding author. Mailing address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. Phone: (852) 2632-3333. Fax: (852) 2647-3227. E-mail: paulkschan{at}cuhk.edu.hk.

Journal of Clinical Microbiology, July 2000, p. 2772-2773, Vol. 38, No. 7
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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Copyright © 2000 by the American Society for Microbiology. All rights reserved.