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Journal of Clinical Microbiology, August 2000, p. 2873-2877, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Enteric Virus Infections and Diarrhea in Healthy and Human Immunodeficiency Virus-Infected Children

Mary B. Liste,1 Ivelisse Natera,2 José A. Suarez,2 Flor H. Pujol,1 Ferdinando Liprandi,1 and Juan E. Ludert1,*

Center for Microbiology and Cell Biology, Instituto Venezolano de Investigaciones Cientificas,1 and Infectology Service, Hospital for Children J. M. de los Ríos,2 Caracas, Venezuela

Received 19 January 2000/Returned for modification 3 April 2000/Accepted 30 May 2000

Forty-three stool samples from 27 human immunodeficiency virus (HIV)-seropositive children and 38 samples from 38 HIV-negative children, collected during a 15-month period, were examined for enteric viruses. Diagnostic assays included enzyme immunoassays for rotavirus, adenovirus, and Norwalk virus; polyacrylamide gel electrophoresis for picobirnavirus and atypical rotavirus; and PCR for astrovirus and enterovirus. Specimens from HIV-positive children were more likely than those of HIV-negative children to have enterovirus (56 versus 21%; P < 0.0002) and astrovirus (12 versus 0%; P < 0.02), but not rotavirus (5 versus 8%; P > 0.5). No adenoviruses, picobirnaviruses, or Norwalk viruses were found. The rates of virus-associated diarrhea were similar among HIV-positive and HIV-negative children. Enteroviruses were excreted for up to 6 months in HIV-positive children; however, no evidence for prolonged excretion of poliovirus vaccine was observed. These results suggest that although infection with enterovirus and astrovirus may be frequent in HIV-infected children, enteric viruses are not associated with the diarrhea frequently suffered by these children.

* Corresponding author. Mailing address: Center for Microbiology and Cell Biology, IVIC, Carretera Panamericana, km. 11, Apdo. 21827, Caracas 1020-A, Venezuela. Phone: 58-2-5041655. Fax: 58-2-5041382. E-mail: jeludert{at}pasteur.ivic.ve.

Journal of Clinical Microbiology, August 2000, p. 2873-2877, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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