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Journal of Clinical Microbiology, August 2000, p. 3098-3099, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Detection of Rabies Virus Antigen in Dog Saliva Using a Latex Agglutination Test

S. Kasempimolporn,* W. Saengseesom, B. Lumlertdacha, and V. Sitprija

Queen Saovabha Memorial Institute (World Health Organization Collaborating Center for Research on Rabies Pathogenesis and Prevention), Thai Red Cross Society, Bangkok, Thailand

Received 7 October 1999/Returned for modification 26 February 2000/Accepted 29 May 2000

Dog bites are responsible for more than 90% of human rabies deaths in Asia. We developed a simple and inexpensive test based on latex agglutination (LA) for rabies virus antigen detection in dog saliva. Rabies virus antigen could be detected by agglutination on a glass slide using latex particles coated with gamma globulin. By evaluation of paired saliva-brain specimens from 238 dogs, the LA test using saliva was 99% specific and 95% sensitive compared to the fluorescent antibody test (FAT) on brain smears. The advantages of the LA test over the standard FAT are that it is comparatively simple and there is no need to kill the animal before examination.

* Corresponding author. Mailing address: Queen Saovabha Memorial Institute, Thai Red Cross Society, 1871 Rama IV Rd., Bangkok 10330, Thailand. Phone: (662)2520161. Fax: (662)2540212. E-mail: qsmiskp{at}redcross.or.th.

Journal of Clinical Microbiology, August 2000, p. 3098-3099, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Xu, X., Jin, M., Yu, Z., Li, H., Qiu, D., Tan, Y., Chen, H. (2005). Latex Agglutination Test for Monitoring Antibodies to Avian Influenza Virus Subtype H5N1. J. Clin. Microbiol. 43: 1953-1955 [Abstract] [Full Text]  


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