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Journal of Clinical Microbiology, August 2000, p. 3100-3102, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Lactoferrin and Eosinophilic Cationic Protein in Nasal Secretions of Patients with Experimental Rhinovirus Colds, Natural Colds, and Presumed Acute Community-Acquired Bacterial Sinusitis

Mark D. Niehaus,1 Jack M. Gwaltney Jr.,2 J. Owen Hendley,3 Mercy J. Newman,4 Peter W. Heymann,5 Gary P. Rakes,5 Thomas A. E. Platts-Mills,6 and Richard L. Guerrant1,*

Divisions of Geographic and International Medicine,1 Epidemiology and Virology,2 and Allergy,6 Department of Medicine, and Divisions of Infectious Diseases3 and Allergy,5 Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, and University of Ghana Medical School, Accra, Ghana4

Received 6 January 2000/Returned for modification 29 March 2000/Accepted 17 May 2000

To distinguish sinusitis from uncomplicated "colds," we examined lactoferrin and eosinophilic cationic protein (ECP) in nasal secretions. Lactoferrin titers were >= 1:400 in 4% of persons with uncomplicated colds and controls but in 79% of persons with sinusitis or purulent sputa. ECP levels were >200 ng/ml in 61% of persons with colds and >3,000 ng/ml in 62% of persons with sinusitis. Nasal lactoferrin helps distinguish sinusitis from colds.

* Corresponding author. Mailing address: Division of Geographic and International Medicine, University of Virginia School of Medicine, Box 801379, Bldg. MR-4, Room 3146, Lane Rd., Charlottesville, VA 22908. Phone: (804) 924-5242. Fax: (804) 977-5323. E-mail: rlg9a{at}virginia.edu.

Journal of Clinical Microbiology, August 2000, p. 3100-3102, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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