This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Valim, A. R. M.
Right arrow Articles by Zaha, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Valim, A. R. M.
Right arrow Articles by Zaha, A.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, August 2000, p. 3119-3122, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Isolates from Brazil

Andréia Rosane M. Valim,1,2 Maria Lucia R. Rossetti,1 Marta O. Ribeiro,1 and Arnaldo Zaha2,*

Laboratório Central do Rio Grande do Sul, Fundação Estadual de Produção e Pesquisa em Saúde, Porto Alegre---Rio Grande do Sul CEP 90130-001,1 and Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre---Rio Grande do Sul CEP 91501-970,2 Brazil

Received 21 March 2000/Returned for modification 16 April 2000/Accepted 29 May 2000

Mutations in a 69-bp region of the rpoB gene associated with rifampin resistance (Rifr) in 100 isolates (82 Rifr) from three states of Brazil were studied. Twenty-one different kinds of mutations were identified in the Rifr isolates, and six new alleles are described.

* Corresponding author. Mailing address: Centro de Biotecnologia/UFRGS, Av. Bento Gonçalves 9500, Prédio 43421, CEP 91501-970 Porto Alegre---RS, Brazil. Phone: 55 51 316-6070. Fax: 55 51 319-1079. E-mail: zaha{at}dna.cbiot.ufrgs.br.

Journal of Clinical Microbiology, August 2000, p. 3119-3122, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • O'Sullivan, D. M., McHugh, T. D., Gillespie, S. H. (2005). Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?. J Antimicrob Chemother 55: 674-679 [Abstract] [Full Text]  
  • Lee, A. S. G., Lim, I. H. K., Tang, L. L. H., Wong, S. Y. (2005). High Frequency of Mutations in the rpoB Gene in Rifampin-Resistant Clinical Isolates of Mycobacterium tuberculosis from Singapore. J. Clin. Microbiol. 43: 2026-2027 [Full Text]  
  • Jou, R., Chen, H.-Y., Chiang, C.-Y., Yu, M.-C., Su, I.-J. (2005). Genetic Diversity of Multidrug-Resistant Mycobacterium tuberculosis Isolates and Identification of 11 Novel rpoB Alleles in Taiwan. J. Clin. Microbiol. 43: 1390-1394 [Abstract] [Full Text]  
  • Yam, W. C., Tam, C. M., Leung, C. C., Tong, H. L., Chan, K. H., Leung, E. T. Y., Wong, K. C., Yew, W. W., Seto, W. H., Yuen, K. Y., Ho, P. L. (2004). Direct Detection of Rifampin-Resistant Mycobacterium tuberculosis in Respiratory Specimens by PCR-DNA Sequencing. J. Clin. Microbiol. 42: 4438-4443 [Abstract] [Full Text]  
  • Silva, M. S. N., Senna, S. G., Ribeiro, M. O., Valim, A. R. M., Telles, M. A., Kritski, A., Morlock, G. P., Cooksey, R. C., Zaha, A., Rossetti, M. L. R. (2003). Mutations in katG, inhA, and ahpC Genes of Brazilian Isoniazid-Resistant Isolates of Mycobacterium tuberculosis. J. Clin. Microbiol. 41: 4471-4474 [Abstract] [Full Text]  
  • Yue, J., Shi, W., Xie, J., Li, Y., Zeng, E., Wang, H. (2003). Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Isolates from China. J. Clin. Microbiol. 41: 2209-2212 [Abstract] [Full Text]  
  • Fan, X.-Y., Hu, Z.-Y., Xu, F.-H., Yan, Z.-Q., Guo, S.-Q., Li, Z.-M. (2003). Rapid Detection of rpoB Gene Mutations in Rifampin-Resistant Mycobacterium tuberculosis Isolates in Shanghai by Using the Amplification Refractory Mutation System. J. Clin. Microbiol. 41: 993-997 [Abstract] [Full Text]  
  • Van Der Zanden, A. G. M., Te Koppele-Vije, E. M., Vijaya Bhanu, N., Van Soolingen, D., Schouls, L. M. (2003). Use of DNA Extracts from Ziehl-Neelsen-Stained Slides for Molecular Detection of Rifampin Resistance and Spoligotyping of Mycobacterium tuberculosis. J. Clin. Microbiol. 41: 1101-1108 [Abstract] [Full Text]  
  • Hwang, H.-Y., Chang, C.-Y., Chang, L.-L., Chang, S.-F., Chang, Y.-H., Chen, Y.-J. (2003). Characterization of rifampicin-resistant Mycobacterium tuberculosis in Taiwan. J Med Microbiol 52: 239-245 [Abstract] [Full Text]  
  • Cavusoglu, C., Hilmioglu, S., Guneri, S., Bilgic, A. (2002). Characterization of rpoB Mutations in Rifampin-Resistant Clinical Isolates of Mycobacterium tuberculosis from Turkey by DNA Sequencing and Line Probe Assay. J. Clin. Microbiol. 40: 4435-4438 [Abstract] [Full Text]  
  • Qian, L., Abe, C., Lin, T.-P., Yu, M.-C., Cho, S.-N., Wang, S., Douglas, J. T. (2002). rpoB Genotypes of Mycobacterium tuberculosis Beijing Family Isolates from East Asian Countries. J. Clin. Microbiol. 40: 1091-1094 [Abstract] [Full Text]  
  • Bartfai, Z., Somoskovi, A., Kodmon, C., Szabo, N., Puskas, E., Kosztolanyi, L., Farago, E., Mester, J., Parsons, L. M., Salfinger, M. (2001). Molecular Characterization of Rifampin-Resistant Isolates of Mycobacterium tuberculosis from Hungary by DNA Sequencing and the Line Probe Assay. J. Clin. Microbiol. 39: 3736-3739 [Abstract] [Full Text]  
  • Mani, C., Selvakumar, N., Narayanan, S., Narayanan, P. R. (2001). Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates from India. J. Clin. Microbiol. 39: 2987-2990 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»