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Journal of Clinical Microbiology, August 2000, p. 3119-3122, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Isolates from Brazil

Andréia Rosane M. Valim,1,2 Maria Lucia R. Rossetti,1 Marta O. Ribeiro,1 and Arnaldo Zaha2,*

Laboratório Central do Rio Grande do Sul, Fundação Estadual de Produção e Pesquisa em Saúde, Porto Alegre---Rio Grande do Sul CEP 90130-001,1 and Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre---Rio Grande do Sul CEP 91501-970,2 Brazil

Received 21 March 2000/Returned for modification 16 April 2000/Accepted 29 May 2000

Mutations in a 69-bp region of the rpoB gene associated with rifampin resistance (Rifr) in 100 isolates (82 Rifr) from three states of Brazil were studied. Twenty-one different kinds of mutations were identified in the Rifr isolates, and six new alleles are described.

* Corresponding author. Mailing address: Centro de Biotecnologia/UFRGS, Av. Bento Gonçalves 9500, Prédio 43421, CEP 91501-970 Porto Alegre---RS, Brazil. Phone: 55 51 316-6070. Fax: 55 51 319-1079. E-mail: zaha{at}dna.cbiot.ufrgs.br.

Journal of Clinical Microbiology, August 2000, p. 3119-3122, Vol. 38, No. 8
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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