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Journal of Clinical Microbiology, September 2000, p. 3442-3444, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Detection and Quantitation of Hepatitis C Virus RNA in Feces of Chronically Infected Individuals

Marcel Beld,1,* Roel Sentjens,2 Sjoerd Rebers,1 Jan Weel,1 Pauline Wertheim-van Dillen,1 Cees Sol,1 and René Boom1

Academic Medical Center, Department of Medical Microbiology, Laboratory of Clinical Virology,1 and Department of Gastro-Enterology and Hepatology,2 Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 14 February 2000/Returned for modification 3 May 2000/Accepted 9 June 2000

Hepatitis C virus (HCV) RNA was detected and quantified in human fecal specimens with the Roche COBAS AMPLICOR system adapted by us for fecal specimens. HCV RNA could be detected in the feces of four of six (67%) patients chronically infected with HCV, with loads up to about 2.8 × 105 copies/ml of feces. The same HCV genotypes were observed in feces and plasma as determined by direct sequencing of the 5' untranslated region.

* Corresponding author. Mailing address: Academic Medical Center, Department of Medical Microbiology, Laboratory of Clinical Virology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. Phone: 020-5665472. Fax: 020-6914005. E-mail: m.beld{at}amc.uva.nl.

Journal of Clinical Microbiology, September 2000, p. 3442-3444, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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