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Journal of Clinical Microbiology, September 2000, p. 3453-3456, Vol. 38, No. 9
Public Health Research
Institute1 and Department of
Microbiology, New York University School of
Medicine,2 New York, New York 10016, and
MIDI Labs, Inc., Newark, Delaware 197133
Received 24 January 2000/Returned for modification 4 May
2000/Accepted 13 June 2000
Coagulase gene (coa) short sequence repeat region
sequencing was used to measure relatedness among a collection of
temporally and geographically diverse methicillin-resistant
Staphylococcus aureus isolates. The results show that
coa polymorphism is free of strong selective pressure and
has a low index of variation that may be useful for long-term
epidemiological investigations. coa typing is a useful
addition to spa typing for analysis of S. aureus, including methicillin-resistant strains.
0095-1137/00/$04.00+0
Use of Coagulase Gene (coa) Repeat Region Nucleotide
Sequences for Typing of Methicillin-Resistant Staphylococcus
aureus Strains
*
Corresponding author. Mailing address: PHRI TB Center,
455 First Ave., New York, NY 10016. Phone: (212) 578-0850. Fax: (212) 578-0853. E-mail: barry{at}phri.org.
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