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Journal of Clinical Microbiology, September 2000, p. 3502-3504, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparison of a Ligase Chain Reaction-Based Assay and Cell Culture for Detection of Pharyngeal Carriage of Chlamydia trachomatis

Andrew J. Winter,1,* Gerry Gilleran,1 Kirstine Eastick,2 and Jonathan D. C. Ross1

Department of Genitourinary Medicine, Whittall St. Clinic, Birmingham,1 and Public Health Laboratory Service Genitourinary Infections Reference Laboratory, Bristol,2 United Kingdom

Received 1 March 2000/Returned for modification 11 May 2000/Accepted 23 June 2000

In 264 genitourinary medicine clinic attenders reporting recent fellatio, the prevalence of pharyngeal Chlamydia trachomatis determined by an expanded standard including cell culture and two in-house PCR tests was 1.5% in 194 women and zero in 70 men. The ligase chain reaction (Abbott LCx) had a specificity of 99.2% and a positive predictive value of 60%.

* Corresponding author. Mailing address: Department of Genitourinary Medicine, 6 Sandyford Pl., Souciehall St., Glasgow, G3 7NB, United Kingdom. Phone: 44 141 211 8601. Fax: 44 141 211 8603. E-mail: Andy_Winter{at}talk21.com.

Journal of Clinical Microbiology, September 2000, p. 3502-3504, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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