Multilocus Sequence Typing System for Campylobacter jejuni

doi:10.1128/JCM.39.1.14-23.2001

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Journal of Clinical Microbiology, January 2001, p. 14-23, Vol. 39, No. 1
0095-1137/01/$04.00+0 DOI: 10.1128/JCM.39.1.14-23.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multilocus Sequence Typing System for Campylobacter jejuni

K. E. Dingle,¹ F. M. Colles,¹ D. R. A. Wareing,² R. Ure,² A. J. Fox,³ F. E. Bolton,² H. J. Bootsma,⁴^, R. J. L. Willems,⁴ R. Urwin,¹ and M. C. J. Maiden¹^,^*

Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY,¹ The Public Health Laboratory, Royal Preston Hospital, Preston PR2 9HG,² and The Public Health Laboratory, Withington Hospital, Manchester M20 8LR,³ United Kingdom, and Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands⁴

Received 20 June 2000/Returned for modification 4 September 2000/Accepted 16 October 2000

The gram-negative bacterium Campylobacter jejuni has extensive reservoirs in livestock and the environment and is a frequentcause of gastroenteritis in humans. To date, the lack of (i) methodssuitable for population genetic analysis and (ii) a universallyaccepted nomenclature has hindered studies of the epidemiologyand population biology of this organism. Here, a multilocus sequencetyping (MLST) system for this organism is described, which exploitsthe genetic variation present in seven housekeeping loci to determinethe genetic relationships among isolates. The MLST system wasestablished using 194 C. jejuni isolates of diverse origins, fromhumans, animals, and the environment. The allelic profiles, orsequence types (STs), of these isolates were deposited on theInternet (http://mlst.zoo.ox.ac.uk), forming a virtual isolatecollection which could be continually expanded. These data indicatedthat C. jejuni is genetically diverse, with a weakly clonal populationstructure, and that intra- and interspecies horizontal geneticexchange was common. Of the 155 STs observed, 51 (26% of the isolatecollection) were unique, with the remainder of the collectionbeing categorized into 11 lineages or clonal complexes of relatedSTs with between 2 and 56 members. In some cases membership ina given lineage or ST correlated with the possession of a particularPenner HS serotype. Application of this approach to further isolatecollections will enable an integrated global picture of C. jejuniepidemiology to be established and will permit more detailed studiesof the population genetics of thisorganism.

^* Corresponding author. Mailing address: Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology,University of Oxford, South Parks Rd., Oxford OX1 3FY, UnitedKingdom. Phone: [44] (1865) 271284. Fax: [44] (1865) 271284. E-mail:martin.maiden{at}zoo.ox.ac.uk.

Present address: Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095-1747.

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Sails, A. D., Swaminathan, B., Fields, P. I. (2003). Utility of Multilocus Sequence Typing as an Epidemiological Tool for Investigation of Outbreaks of Gastroenteritis Caused by Campylobacter jejuni. J. Clin. Microbiol. 41: 4733-4739 [Abstract] [Full Text]
Wiesner, R. S., Hendrixson, D. R., DiRita, V. J. (2003). Natural Transformation of Campylobacter jejuni Requires Components of a Type II Secretion System. J. Bacteriol. 185: 5408-5418 [Abstract] [Full Text]
Sails, A. D., Swaminathan, B., Fields, P. I. (2003). Clonal Complexes of Campylobacter jejuni Identified by Multilocus Sequence Typing Correlate with Strain Associations Identified by Multilocus Enzyme Electrophoresis. J. Clin. Microbiol. 41: 4058-4067 [Abstract] [Full Text]
Tavanti, A., Gow, N. A. R., Senesi, S., Maiden, M. C. J., Odds, F. C. (2003). Optimization and Validation of Multilocus Sequence Typing for Candida albicans. J. Clin. Microbiol. 41: 3765-3776 [Abstract] [Full Text]
Jones, N., Bohnsack, J. F., Takahashi, S., Oliver, K. A., Chan, M.-S., Kunst, F., Glaser, P., Rusniok, C., Crook, D. W. M., Harding, R. M., Bisharat, N., Spratt, B. G. (2003). Multilocus Sequence Typing System for Group B Streptococcus. J. Clin. Microbiol. 41: 2530-2536 [Abstract] [Full Text]
Meats, E., Feil, E. J., Stringer, S., Cody, A. J., Goldstein, R., Kroll, J. S., Popovic, T., Spratt, B. G. (2003). Characterization of Encapsulated and Noncapsulated Haemophilus influenzae and Determination of Phylogenetic Relationships by Multilocus Sequence Typing. J. Clin. Microbiol. 41: 1623-1636 [Abstract] [Full Text]
Salcedo, C., Arreaza, L., Alcala, B., de la Fuente, L., Vazquez, J. A. (2003). Development of a Multilocus Sequence Typing Method for Analysis of Listeria monocytogenes Clones. J. Clin. Microbiol. 41: 757-762 [Abstract] [Full Text]
Schouls, L. M., Reulen, S., Duim, B., Wagenaar, J. A., Willems, R. J. L., Dingle, K. E., Colles, F. M., Van Embden, J. D. A. (2003). Comparative Genotyping of Campylobacter jejuni by Amplified Fragment Length Polymorphism, Multilocus Sequence Typing, and Short Repeat Sequencing: Strain Diversity, Host Range, and Recombination. J. Clin. Microbiol. 41: 15-26 [Abstract] [Full Text]
Viscidi, R. P., Demma, J. C. (2003). Genetic Diversity of Neisseria gonorrhoeae Housekeeping Genes. J. Clin. Microbiol. 41: 197-204 [Abstract] [Full Text]
King, S. J., Leigh, J. A., Heath, P. J., Luque, I., Tarradas, C., Dowson, C. G., Whatmore, A. M. (2002). Development of a Multilocus Sequence Typing Scheme for the Pig Pathogen Streptococcus suis: Identification of Virulent Clones and Potential Capsular Serotype Exchange. J. Clin. Microbiol. 40: 3671-3680 [Abstract] [Full Text]
Cai, S., Kabuki, D. Y., Kuaye, A. Y., Cargioli, T. G., Chung, M. S., Nielsen, R., Wiedmann, M. (2002). Rational Design of DNA Sequence-Based Strategies for Subtyping Listeria monocytogenes. J. Clin. Microbiol. 40: 3319-3325 [Abstract] [Full Text]
Homan, W. L., Tribe, D., Poznanski, S., Li, M., Hogg, G., Spalburg, E., van Embden, J. D. A., Willems, R. J. L. (2002). Multilocus Sequence Typing Scheme for Enterococcus faecium. J. Clin. Microbiol. 40: 1963-1971 [Abstract] [Full Text]
van Loo, I. H. M., Heuvelman, K. J., King, A. J., Mooi, F. R. (2002). Multilocus Sequence Typing of Bordetella pertussis Based on Surface Protein Genes. J. Clin. Microbiol. 40: 1994-2001 [Abstract] [Full Text]
Kotetishvili, M., Stine, O. C., Kreger, A., Morris, J. G. Jr., Sulakvelidze, A. (2002). Multilocus Sequence Typing for Characterization of Clinical and Environmental Salmonella Strains. J. Clin. Microbiol. 40: 1626-1635 [Abstract] [Full Text]
Bougnoux, M.-E., Morand, S., d'Enfert, C. (2002). Usefulness of Multilocus Sequence Typing for Characterization of Clinical Isolates of Candida albicans. J. Clin. Microbiol. 40: 1290-1297 [Abstract] [Full Text]
Ahmed, I. H., Manning, G., Wassenaar, T. M., Cawthraw, S., Newell, D. G. (2002). Identification of genetic differences between two Campylobacter jejuni strains with different colonization potentials. Microbiology 148: 1203-1212 [Abstract] [Full Text]
Nallapareddy, S. R., Duh, R.-W., Singh, K. V., Murray, B. E. (2002). Molecular Typing of Selected Enterococcus faecalis Isolates: Pilot Study Using Multilocus Sequence Typing and Pulsed-Field Gel Electrophoresis. J. Clin. Microbiol. 40: 868-876 [Abstract] [Full Text]
Oza, A. N., Thwaites, R. T., Wareing, D. R. A., Bolton, F. J., Frost, J. A. (2002). Detection of Heat-Stable Antigens of Campylobacter jejuni and C. coli by Direct Agglutination and Passive Hemagglutination. J. Clin. Microbiol. 40: 996-1000 [Abstract] [Full Text]
Desai, M., Logan, J. M. J., Frost, J. A., Stanley, J. (2001). Genome Sequence-Based Fluorescent Amplified Fragment Length Polymorphism of Campylobacter jejuni, Its Relationship to Serotyping, and Its Implications for Epidemiological Analysis. J. Clin. Microbiol. 39: 3823-3829 [Abstract] [Full Text]
Dingle, K. E., Van Den Braak, N., Colles, F. M., Price, L. J., Woodward, D. L., Rodgers, F. G., Endtz, H. P., Van Belkum, A., Maiden, M. C. J. (2001). Sequence Typing Confirms that Campylobacter jejuni Strains Associated with Guillain-Barre and Miller-Fisher Syndromes Are of Diverse Genetic Lineage, Serotype, and Flagella Type. J. Clin. Microbiol. 39: 3346-3349 [Abstract] [Full Text]
Fitzgerald, C., Helsel, L. O., Nicholson, M. A., Olsen, S. J., Swerdlow, D. L., Flahart, R., Sexton, J., Fields, P. I. (2001). Evaluation of Methods for Subtyping Campylobacter jejuni during an Outbreak Involving a Food Handler. J. Clin. Microbiol. 39: 2386-2390 [Abstract] [Full Text]
Suerbaum, S., Lohrengel, M., Sonnevend, A., Ruberg, F., Kist, M. (2001). Allelic Diversity and Recombination in Campylobacter jejuni. J. Bacteriol. 183: 2553-2559 [Abstract] [Full Text]
Gilbert, M., Karwaski, M.-F., Bernatchez, S., Young, N. M., Taboada, E., Michniewicz, J., Cunningham, A.-M., Wakarchuk, W. W. (2002). The Genetic Bases for the Variation in the Lipo-oligosaccharide of the Mucosal Pathogen, Campylobacter jejuni. BIOSYNTHESIS OF SIALYLATED GANGLIOSIDE MIMICS IN THE CORE OLIGOSACCHARIDE. J. Biol. Chem. 277: 327-337 [Abstract] [Full Text]
Dorrell, N., Mangan, J. A., Laing, K. G., Hinds, J., Linton, D., Al-Ghusein, H., Barrell, B. G., Parkhill, J., Stoker, N. G., Karlyshev, A. V., Butcher, P. D., Wren, B. W. (2001). Whole Genome Comparison of Campylobacter jejuni Human Isolates Using a Low-Cost Microarray Reveals Extensive Genetic Diversity. Genome Res 11: 1706-1715 [Abstract] [Full Text]

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