This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Werner, G.
Right arrow Articles by Witte, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Werner, G.
Right arrow Articles by Witte, W.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2001, p. 3586-3590, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3586-3590.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Methicillin-Resistant, Quinupristin-Dalfopristin-Resistant Staphylococcus aureus with Reduced Sensitivity to Glycopeptides

G. Werner,1 C. Cuny,1 F.-J. Schmitz,2 and W. Witte1,*

Wernigerode Branch, Robert Koch Institute, D-38855 Wernigerode,1 and Institute of Medical Microbiology and Immunology, Düsseldorf University, D-40225 Düsseldorf,2 Germany

Received 24 January 2001/Returned for modification 8 June 2001/Accepted 11 July 2001

Of 3,052 Staphylococcus aureus strains collected by the European SENTRY surveillance study, 35 were found to be nonsusceptible to quinupristin-dalfopristin (MIC of >= 2 mg/liter). These isolates originated from four hospitals in France and one in Spain. In isolates from two Parisian hospitals exhibiting the same SmaI macrorestriction pattern, streptogramin resistance was based on vatA and vgbA. One isolate from a hospital in Lyon and 22 from a hospital in Lille were of the vatB vgaB streptogramin A resistance genotype and possessed ermA and/or ermC. As deduced from the loss of either streptogramin A or streptogramin B resistance determinants in particular isolates, resistance to quinupristin-dalfopristin requires mechanisms conferring resistance to both compounds. The SmaI macrorestriction patterns of strains from hospitals in Lille and Lyon were different; however, similarity analysis suggested a relatedness of 20 methicillin-resistant S. aureus strains from the Lille hospital, a finding confirmed by PCR typing based on three different genomic polymorphisms. These groups of isolates were found to be hetero-glycopeptide-intermediate susceptible S. aureus. Information about the failure of glycopeptide chemotherapy has not been available.

* Corresponding author. Mailing address: Robert Koch Institute, Wernigerode Branch, Burgstr. 37, 38855 Wernigerode, Germany. Phone: 0049-3943-679246. Fax: 0049-3943-679317. E-mail: wittew{at}rki.de.

Journal of Clinical Microbiology, October 2001, p. 3586-3590, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3586-3590.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Petrelli, D., Repetto, A., D'Ercole, S., Rombini, S., Ripa, S., Prenna, M., Vitali, L. A. (2008). Analysis of meticillin-susceptible and meticillin-resistant biofilm-forming Staphylococcus aureus from catheter infections isolated in a large Italian hospital. J Med Microbiol 57: 364-372 [Abstract] [Full Text]  
  • Ng, J., Gosbell, I. B. (2005). Successful oral pristinamycin therapy for osteoarticular infections due to methicillin-resistant Staphylococcus aureus (MRSA) and other Staphylococcus spp.. J Antimicrob Chemother 55: 1008-1012 [Abstract] [Full Text]  
  • Strommenger, B., Kettlitz, C., Werner, G., Witte, W. (2003). Multiplex PCR Assay for Simultaneous Detection of Nine Clinically Relevant Antibiotic Resistance Genes in Staphylococcus aureus. J. Clin. Microbiol. 41: 4089-4094 [Abstract] [Full Text]  
  • Haroche, J., Morvan, A., Davi, M., Allignet, J., Bimet, F., El Solh, N. (2003). Clonal Diversity among Streptogramin A-Resistant Staphylococcus aureus Isolates Collected in French Hospitals. J. Clin. Microbiol. 41: 586-591 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»