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Journal of Clinical Microbiology, October 2001, p. 3760-3763, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3760-3763.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Longitudinal Variability of Human Immunodeficiency Virus Type 1 RNA Viral Load Measurements by Nucleic Acid Sequence-Based Amplification and NucliSens Assays in a Large Multicenter Study

Marek J. Nowicki,1,* Lorie Benning,2 James W. Bremer,3 William A. Meyer III,4 Carl Hanson,5 Donald Brambilla,6 Sylvia Silver,7 Andrea Kovacs,1 and the Women's Interagency HIV-1 Study Collaborative Study Group

University of Southern California, Los Angeles,1 and California State Department of Health, Berkeley,5 California; Johns Hopkins School of Public Health Department of Epidemiology,2 and Quest Diagnostics Incorporated,4 Baltimore, Maryland; Rush Medical College, Chicago, Illinois3; New England Research Institutes, Watertown, Massachusetts6 and Office of HIV-1 Activities, The George Washington University Medical Center, Washington, D.C.7

Received 2 March 2001/Returned for modification 15 May 2001/Accepted 10 July 2001

Human immunodeficiency virus type 1 (HIV-1) RNA measurements were evaluated within an externally controlled multilaboratory program. Three external standards (1.5 × 103 to 1.5 × 106 copies/ml) were included in 814 assay runs by four laboratories. Results indicate that HIV-1 RNA levels can be measured with a precision equal to that of the pre-highly active antiretroviral therapy era (standard deviations, ±0.16 to 0.25 log10 units).

* Corresponding author. Mailing address: University of Southern California, Pediatrics, 1801 E. Marengo St., Room 2G11, Los Angeles, CA 90033. Phone: (323) 226-4161. Fax: (323) 226-3831. E-mail: marek{at}usc.edu.

Journal of Clinical Microbiology, October 2001, p. 3760-3763, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3760-3763.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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