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Journal of Clinical Microbiology, November 2001, p. 4184-4186, Vol. 39, No. 11
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.11.4184-4186.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Sequence Polymorphism in the rrs Gene of Mycobacterium tuberculosis Is Deeply Rooted within an Evolutionary Clade and Is Not Associated with Streptomycin Resistance

Thomas C. Victor,1,* Annelies van Rie,2 Annemie M. Jordaan,1 Madalene Richardson,1 Gian D. van der Spuy,1 Nulda Beyers,2 Paul D. van Helden,1 and Robin Warren1

MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry,1 and Department of Pediatrics and Child Health,2 University of Stellenbosch, Stellenbosch, South Africa

Received 26 March 2001/Returned for modification 19 July 2001/Accepted 9 August 2001

A mutation (C-to-T transition) at position 491 of the rrs gene was identified in a Mycobacterium tuberculosis strain family (n = 208 isolates) that was predominant in a suburb of Cape Town, South Africa. This nucleotide change is not involved in streptomycin resistance, and we suggest caution in assuming that all mutations in genes targeted by antituberculosis drugs confer drug resistance.

* Corresponding author. Mailing address: Department of Medical Biochemistry, University of Stellenbosch, Stellenbosch, South Africa. Phone: 27-21-9389251. Fax: 27-21-9317810. E-mail: TV{at}gerga.sun.ac.za.

Journal of Clinical Microbiology, November 2001, p. 4184-4186, Vol. 39, No. 11
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.11.4184-4186.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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