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Journal of Clinical Microbiology, November 2001, p. 4208-4209, Vol. 39, No. 11
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.11.4208-4209.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activity of Posaconazole against Clinical Isolates of Dermatophytes

Francesco Barchiesi,1,* Daniela Arzeni,1 Valeria Camiletti,1 Oriana Simonetti,2 Andreina Cellini,2 Anna M. Offidani,2 and Giorgio Scalise1

Istituto di Malattie Infettive e Medicina Pubblica1 and Clinica Dermatologica,2 Università degli Studi di Ancona, Ancona, Italy

Received 9 March 2001/Returned for modification 1 April 2001/Accepted 3 September 2001

A broth macrodilution method following the recommendations established by the National Committee for Clinical Laboratory Standards was used to compare the in vitro activity of posaconazole (PCZ) with that of itraconazole (ITC) against 30 clinical isolates of dermatophytes belonging to six different species. In terms of MICs, PCZ showed an activity equal to that of ITC. MICs of PCZ at which 50% (MIC50) and 90% (MIC90) of the isolates were inhibited were 0.5 and >4.0 µg/ml, respectively. The MIC50 and MIC90 of ITC were 1.0 and >4.0 µg/ml, respectively. However, PCZ showed a more potent fungicidal activity than that of ITC against isolates belonging to the genus Microsporum (P = 0.03). PCZ merits further investigation as a potentially useful agent for treatment of dermatophytosis.

* Corresponding author. Mailing address: Istituto di Malattie Infettive e Medicina Pubblica, Università degli Studi di Ancona, Azienda Ospedaliera Umberto I°, Via Conca, 60020, Ancona, Italy. Phone: 39.71.5963467. Fax: 39.71.5963468. E-mail: cmalinf{at}popcsi.unian.it.

Journal of Clinical Microbiology, November 2001, p. 4208-4209, Vol. 39, No. 11
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.11.4208-4209.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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