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Journal of Clinical Microbiology, December 2001, p. 4349-4356, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4349-4356.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Staphylococcus aureus Isolated in Cases of Impetigo Produces Both Epidermolysin A or B and LukE-LukD in 78% of 131 Retrospective and Prospective Cases

A. Gravet,1 P. Couppié,2 O. Meunier,3 E. Clyti,2 B. Moreau,4 R. Pradinaud,2 H. Monteil,1 and G. Prévost1,*

Institut de Bactériologie de la Faculté de Médecine de Strasbourg---Hôpitaux Universitaires de Strasbourg,1 and Institut d'Hygiène de la Faculté de Médecine de Strasbourg---Hôpitaux Universitaires de Strasbourg,3 F-67000 Strasbourg, and Institut Guyanais de Dermatologie Tropicale, Service de Dermatologie,2 and Laboratoire de Bactériologie,4 C.H.G. de Cayenne, 97306 Cayenne Cedex, France

Received 8 May 2001/Returned for modification 1 July 2001/Accepted 8 September 2001

Clinical symptoms of impetigo and staphylococcal scalded skin syndrome may not only be expressed as the splitting of cell layers within the epidermis but are often accompanied by some localized inflammation. Toxin patterns of Staphylococcus aureus isolates originating from patients with impetigo and also from those with other primary and secondary skin infections in a retrospective isolate collection in France and a prospective isolate collection in French Guiana revealed a significant association (75% of the cases studied) of impetigo with production of at least one of the epidermolysins A and B and the bicomponent leucotoxin LukE-LukD (P < 0.001). However, most of the isolates were able to produce one of the nonubiquitous enterotoxins. Pulsed-field gel electrophoresis (PFGE) of genomic DNA hydrolyzed with SmaI showed a polymorphism of the two groups of isolates despite the fact that endemic clones were suspected in French Guiana and France. The combination of toxin patterns with PFGE fingerprinting may provide further discrimination among isolates defined in a given cluster or a given pulsotype and account for a specific virulence. The new association of toxins with a clinical syndrome may reveal principles of the pathological process.

* Corresponding author. Mailing address: Institut de Bactériologie de la Faculté de Médecine de Strasbourg---Hôpitaux Universitaires de Strasbourg 3, rue Koeberlé, F-67000 Strasbourg, France. Phone: 33 3 90 24 37 57. Fax: 33 3 88 25 11 13. E-mail: gilles.prevost{at}medecine.u-strasbg.fr.

Journal of Clinical Microbiology, December 2001, p. 4349-4356, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4349-4356.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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