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Journal of Clinical Microbiology, December 2001, p. 4420-4425, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4420-4425.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multidrug-Resistant Trichosporon asahii Infection of Nongranulocytopenic Patients in Three Intensive Care Units

Dana G. Wolf,1 Rama Falk,1 Moshe Hacham,1 Bart Theelen,2 Teun Boekhout,2 Gloria Scorzetti,3 Mervyn Shapiro,1 Colin Block,1 Ira F. Salkin,4 and Itzhack Polacheck1,*

Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1; CBS Yeast Division, Utrecht, The Netherlands2; Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Key Biscayne, Florida3; and Wadsworth Center, New York State Department of Health, Albany, New York4

Received 8 December 2000/Returned for modification 18 March 2001/Accepted 30 September 2001

Trichosporon asahii (Trichosporon beigelii) infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. We report on the recent recovery of T. asahii isolates with reduced susceptibility in vitro to amphotericin B (AMB), flucytosine, and azoles from six nongranulocytopenic patients who exhibited risk factors and who developed either superficial infections (four individuals) or invasive infections (two individuals) while in intensive care units. The latter two patients responded clinically and microbiologically to AMB treatment. All six isolates were closely related according to random amplified polymorphic DNA studies and showed 71% similarity by amplified fragment length polymorphism analysis, suggesting a common nosocomial origin. We also review the literature pertaining to T. asahii infections and discuss the salient characteristics of this fungus and recent taxonomic proposals for the genus.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, P.O. Box 12000, Jerusalem 91120, Israel. Phone: 972-2-677-6592. Fax: 972-2-676-9206. E-mail: Itzhack.Polacheck{at}huji.ac.il.

Journal of Clinical Microbiology, December 2001, p. 4420-4425, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4420-4425.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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