JCM Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sales, M. P. U.
Right arrow Articles by Shaw, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sales, M. P. U.
Right arrow Articles by Shaw, R. J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, December 2001, p. 4558-4562, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4558-4562.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Genetic Diversity among Mycobacterium bovis Isolates: a Preliminary Study of Strains from Animal and Human Sources

M. P. U. Sales,1 G. M. Taylor,2,* S. Hughes,3 M. Yates,4 G. Hewinson,3 D. B. Young,2 and R. J. Shaw1

Department of Respiratory Medicine, National Heart and Lung Institute,1 and Department of Infectious Diseases and Microbiology,2 Imperial College, London SW7 2AZ, Veterinary Laboratory Agency, New Haw, Addlestone, Surrey KT15 3NB,3 and Public Health Laboratory Service, Mycobacterium Reference Unit, King's College School of Medicine and Dentistry, King's College Hospital, East Dulwich Grove, London SE22 8QF,4 United Kingdom

Received 1 February 2001/Returned for modification 10 July 2001/Accepted 11 September 2001

Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.

* Corresponding author. Mailing address: Department of Infectious Diseases and Microbiology, Imperial College, Flowers Building, Armstrong Rd., London SW7 2AZ, United Kingdom. Phone: 44 (0) 207-594-3090. Fax: 44 (0) 207-594-3095. E-mail: gm.taylor{at}ic.ac.uk.

Journal of Clinical Microbiology, December 2001, p. 4558-4562, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4558-4562.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2001 by the American Society for Microbiology. All rights reserved.