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Journal of Clinical Microbiology, December 2001, p. 4585-4587, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4585-4587.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Fatal Myocarditis Associated with Acute Parvovirus B19 and Human Herpesvirus 6 Coinfection

Jacques Rohayem,1 Jürgen Dinger,2 Rainer Fischer,3 Karin Klingel,4 Reinhard Kandolf,4 and Axel Rethwilm1,*

Institut für Virologie,1 Klinik für Kinderheilkunde,2 and Institut für Pathologie,3 Medizinische Fakultät "Carl Gustav Carus," Technische Universität Dresden, 01307 Dresden, and Abteilung für Molekulare Pathologie, Institut für Pathologie, Universität Tübingen, 72076 Tübingen,4 Germany

Received 3 August 2001/Returned for modification 4 September 2001/Accepted 11 September 2001

We report on the case of a healthy young boy who developed a fulminant myocarditis due to acute coinfection with erythrovirus (parvovirus B19) and human herpesvirus 6 (HHV-6) in the absence of an antiviral immune response. We suggest that the HHV-6-induced immunosuppression enhanced dissemination of parvovirus B19, which led to fatal myocarditis.

* Corresponding author. Mailing address: Institut für Virologie, Medizinische Fakultät, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Phone: 49-351-458 6200. Fax: 49-351-458 6314. E-mail: Axel.Rethwilm{at}mailbox.tu-dresden.de.

Journal of Clinical Microbiology, December 2001, p. 4585-4587, Vol. 39, No. 12
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.12.4585-4587.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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