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Journal of Clinical Microbiology, February 2001, p. 625-630, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.625-630.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nocardia africana sp. nov., a New Pathogen Isolated from Patients with Pulmonary Infections

Mohamed E. Hamid,1,2 Luis Maldonado,2 Ghada S. Sharaf Eldin,3 Maha F. Mohamed,3 Nageeb S. Saeed,3 and Michael Goodfellow2,*

Department of Preventive Medicine and Public Health, Faculty of Veterinary Science, University of Khartoum, Khartoum North,1 and Tuberculosis Reference Laboratory, National Health Laboratory, Khartoum,3 Sudan, and Department of Agricultural and Environmental Science, University of Newcastle, Newcastle upon Tyne NE1 7RU, United Kingdom2

Received 10 July 2000/Returned for modification 23 September 2000/Accepted 21 November 2000

Eight actinomycete strains, isolated from 8 out of 400 sputum samples examined, taken from patients with pulmonary diseases at the Chest Unit of Khartoum Teaching Hospital in the Sudan, were provisionally assigned to the genus Nocardia according to morphological criteria. These isolates were studied further in order to establish their taxonomic status. They were found to have morphological and chemical properties typical of nocardiae and formed a monophyletic clade in the 16S ribosomal DNA tree together with Nocardia vaccinii. The strains showed a unique pattern of phenotypic properties that distinguished them from representatives of recognized Nocardia species, including Nocardia vaccinii. The strains were considered to merit species status and were designated Nocardia africana sp. nov. The findings of the present study are consistent with the view that pulmonary nocardiosis may occur in a substantial proportion of patients who exhibit chronic lung diseases in African countries. It is important, therefore, that clinicians in such countries consider this condition, especially when patients with respiratory infections fail to respond to antitubercular therapy.

* Corresponding author. Mailing address: Department of Agricultural and Environmental Science, University of Newcastle, Newcastle upon Tyne NE1 7RU, United Kingdom. Phone: 44-191-222-7706. Fax: 44-191-222-5228. E-mail: m.goodfellow{at}ncl.ac.uk.

Journal of Clinical Microbiology, February 2001, p. 625-630, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.625-630.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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