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Journal of Clinical Microbiology, February 2001, p. 816-819, Vol. 39, No. 2
0095-1137/01/$04.00+0 DOI: 10.1128/JCM.39.2.816-819.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Fatal Pulmonary Infection Due to
Multidrug-Resistant Mycobacterium abscessus in a Patient
with Cystic Fibrosis
Maurizio
Sanguinetti,1,*
Fausta
Ardito,1
Ersilia
Fiscarelli,2
Marilena
La
Sorda,1
Patrizia
D'Argenio,3
Gabriella
Ricciotti,2 and
Giovanni
Fadda1
Istituto di Microbiologia, Università
Cattolica del S. Cuore,1 and Sezione
Microbiologia,2 and Dipartimento
Immunoinfettivologia,3 Ospedale Pediatrico
"Bambino Gesù," Rome, Italy
Received 12 September 2000/Returned for modification 22 October
2000/Accepted 18 November 2000
We report a case of fatal pulmonary infection caused by
Mycobacterium abscessus in a young patient with cystic
fibrosis, who underwent bipulmonary transplantation after a 1-year
history of severe lung disease. Fifteen days after surgery he developed
septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was
then recovered from repeated blood samples, suggesting a disseminated
nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died.
*
Corresponding author. Mailing address: Istituto di
Microbiologia, Università Cattolica del S. Cuore, Largo F. Vito,
1, 00168 Rome, Italy. Phone: 39-6-30154336. Fax: 39-6-3051152. E-mail: msanguinetti{at}rm.unicatt.it.
Journal of Clinical Microbiology, February 2001, p. 816-819, Vol. 39, No. 2
0095-1137/01/$04.00+0 DOI: 10.1128/JCM.39.2.816-819.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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