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Journal of Clinical Microbiology, February 2001, p. 816-819, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.816-819.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Fatal Pulmonary Infection Due to Multidrug-Resistant Mycobacterium abscessus in a Patient with Cystic Fibrosis

Maurizio Sanguinetti,1,* Fausta Ardito,1 Ersilia Fiscarelli,2 Marilena La Sorda,1 Patrizia D'Argenio,3 Gabriella Ricciotti,2 and Giovanni Fadda1

Istituto di Microbiologia, Università Cattolica del S. Cuore,1 and Sezione Microbiologia,2 and Dipartimento Immunoinfettivologia,3 Ospedale Pediatrico "Bambino Gesù," Rome, Italy

Received 12 September 2000/Returned for modification 22 October 2000/Accepted 18 November 2000

We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of severe lung disease. Fifteen days after surgery he developed septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died.

* Corresponding author. Mailing address: Istituto di Microbiologia, Università Cattolica del S. Cuore, Largo F. Vito, 1, 00168 Rome, Italy. Phone: 39-6-30154336. Fax: 39-6-3051152. E-mail: msanguinetti{at}rm.unicatt.it.

Journal of Clinical Microbiology, February 2001, p. 816-819, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.816-819.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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