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Journal of Clinical Microbiology, February 2001, p. 816-819, Vol. 39, No. 2
Istituto di Microbiologia, Università
Cattolica del S. Cuore,1 and Sezione
Microbiologia,2 and Dipartimento
Immunoinfettivologia,3 Ospedale Pediatrico
"Bambino Gesù," Rome, Italy
Received 12 September 2000/Returned for modification 22 October
2000/Accepted 18 November 2000
We report a case of fatal pulmonary infection caused by
Mycobacterium abscessus in a young patient with cystic
fibrosis, who underwent bipulmonary transplantation after a 1-year
history of severe lung disease. Fifteen days after surgery he developed
septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was
then recovered from repeated blood samples, suggesting a disseminated
nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died.
0095-1137/01/$04.00+0 DOI: 10.1128/JCM.39.2.816-819.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Fatal Pulmonary Infection Due to
Multidrug-Resistant Mycobacterium abscessus in a Patient
with Cystic Fibrosis
*
Corresponding author. Mailing address: Istituto di
Microbiologia, Università Cattolica del S. Cuore, Largo F. Vito,
1, 00168 Rome, Italy. Phone: 39-6-30154336. Fax: 39-6-3051152. E-mail: msanguinetti{at}rm.unicatt.it.
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