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Journal of Clinical Microbiology, March 2001, p. 1195-1196, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.1195-1196.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of IsoCode STIX and FTA Gene Guard Collection Matrices as Whole-Blood Storage and Processing Devices for Diagnosis of Malaria by PCR

Kathleen J. Y. Zhong,1 Carola J. Salas,2 Robyn Shafer,1 Alex Gubanov,1 Robert A. Gasser Jr.,3 Alan J. Magill,2 J. Russ Forney,4 and Kevin C. Kain1

Centre for Travel and Tropical Medicine, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital and the University of Toronto1; Department of Parasitology, U.S. Naval Medical Research Center Detachment, Lima, Peru2; and Department of Immunology3 and Department of Parasitology,4 Walter Reed Army Institute of Research, Silver Spring, Maryland

Received 19 October 2000/Returned for modification 28 November 2000/Accepted 11 December 2000

We compared two collection devices, IsoCode and FTA, with whole blood for the diagnosis of malaria by PCR (n = 100). Using whole blood as the reference standard, both devices were sensitive for the detection of single-species malaria infections by PCR (>= 96%). However, the detection of mixed infections was suboptimal (IsoCode was 42% sensitive, and FTA was 63% sensitive).

Journal of Clinical Microbiology, March 2001, p. 1195-1196, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.1195-1196.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2001 by the American Society for Microbiology. All rights reserved.