This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Gheldre, Y.
Right arrow Articles by Vaneechoutte, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Gheldre, Y.
Right arrow Articles by Vaneechoutte, M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, March 2001, p. 889-896, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.889-896.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

National Epidemiologic Surveys of Enterobacter aerogenes in Belgian Hospitals from 1996 to 1998

Y. De Gheldre,1 M. J. Struelens,1 Y. Glupczynski,2 P. De Mol,3 N. Maes,1 C. Nonhoff,1 H. Chetoui,3 C. Sion,2 O. Ronveaux,4 M. Vaneechoutte,5 and le Groupement Pour Le Dépistage, l'Etude et la Prevention des Infections Hospitalières (gdepih-gospiz)

Service de Microbiologie, Université Libre de Bruxelles-Hôpital Erasme,1 Laboratoire de Microbiologie Médicale, Centre Hospitalier Universitaire de Liège,3 and Institut Scientifique de la Santé Publique,4 Brussels, Laboratoire de Microbiologie, Clinique Universitaire de Mont Godinne, Université Catholique de Louvain, Yvoir,2 and Laboratorium voor Bakteriologie en Virologie, Universitair Ziekenhuis, Ghent,5 Belgium

Received 28 June 2000/Returned for modification 29 August 2000/Accepted 14 November 2000

Two national surveys were conducted to describe the incidence and prevalence of Enterobacter aerogenes in 21 Belgian hospitals in 1996 and 1997 and to characterize the genotypic diversity and the antimicrobial resistance profiles of clinical strains of E. aerogenes isolated from hospitalized patients in Belgium in 1997 and 1998. Twenty-nine hospitals collected 10 isolates of E. aerogenes, which were typed by arbitrarily primed PCR (AP-PCR) using two primers and pulsed-field gel electrophoresis. MICs of 10 antimicrobial agents were determined by the agar dilution method. Beta-lactamases were detected by the double-disk diffusion test and characterized by isoelectric point. The median incidence of E. aerogenes colonization or infection increased from 3.3 per 1,000 admissions in 1996 to 4.2 per 1000 admissions in the first half of 1997 (P < 0.01). E. aerogenes strains (n = 260) clustered in 25 AP-PCR types. Two major types, BE1 and BE2, included 36 and 38% of strains and were found in 21 and 25 hospitals, respectively. The BE1 type was indistinguishable from a previously described epidemic strain in France. Half of the strains produced an extended-spectrum beta-lactamase, either TEM-24 (in 86% of the strains) or TEM-3 (in 14% of the strains). Over 75% of the isolates were resistant to ceftazidime, piperacillin-tazobactam, and ciprofloxacin. Over 90% of the strains were susceptible to cefepime, carbapenems, and aminoglycosides. In conclusion, these data suggest a nationwide dissemination of two epidemic multiresistant E. aerogenes strains in Belgian hospitals. TEM-24 beta-lactamase was frequently harbored by one of these epidemic strains, which appeared to be genotypically related to a TEM-24-producing epidemic strain from France, suggesting international dissemination.

Journal of Clinical Microbiology, March 2001, p. 889-896, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.889-896.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Lorenzi, V., Muselli, A., Bernardini, A. F., Berti, L., Pages, J.-M., Amaral, L., Bolla, J.-M. (2009). Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species. Antimicrob. Agents Chemother. 53: 2209-2211 [Abstract] [Full Text]  
  • Machado, E., Coque, T. M., Canton, R., Sousa, J. C., Peixe, L. (2008). Antibiotic resistance integrons and extended-spectrum {beta}-lactamases among Enterobacteriaceae isolates recovered from chickens and swine in Portugal. J Antimicrob Chemother 62: 296-302 [Abstract] [Full Text]  
  • Dupont, M., James, C. E., Chevalier, J., Pages, J.-M. (2007). An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore-Forming Proteins. Antimicrob. Agents Chemother. 51: 3190-3198 [Abstract] [Full Text]  
  • Livermore, D. M., Canton, R., Gniadkowski, M., Nordmann, P., Rossolini, G. M., Arlet, G., Ayala, J., Coque, T. M., Kern-Zdanowicz, I., Luzzaro, F., Poirel, L., Woodford, N. (2007). CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother 59: 165-174 [Abstract] [Full Text]  
  • Masi, M., Pages, J.-M., Pradel, E. (2006). Production of the cryptic EefABC efflux pump in Enterobacter aerogenes chloramphenicol-resistant mutants. J Antimicrob Chemother 57: 1223-1226 [Abstract] [Full Text]  
  • Paterson, D. L., Bonomo, R. A. (2005). Extended-Spectrum {beta}-Lactamases: a Clinical Update. Clin. Microbiol. Rev. 18: 657-686 [Abstract] [Full Text]  
  • Masi, M., Pages, J.-M., Villard, C., Pradel, E. (2005). The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes. J. Bacteriol. 187: 3894-3897 [Abstract] [Full Text]  
  • Thiolas, A., Bollet, C., La Scola, B., Raoult, D., Pages, J.-M. (2005). Successive Emergence of Enterobacter aerogenes Strains Resistant to Imipenem and Colistin in a Patient. Antimicrob. Agents Chemother. 49: 1354-1358 [Abstract] [Full Text]  
  • Schlesinger, J., Navon-Venezia, S., Chmelnitsky, I., Hammer-Munz, O., Leavitt, A., Gold, H. S., Schwaber, M. J., Carmeli, Y. (2005). Extended-Spectrum Beta-Lactamases among Enterobacter Isolates Obtained in Tel Aviv, Israel. Antimicrob. Agents Chemother. 49: 1150-1156 [Abstract] [Full Text]  
  • Wauters, G., Avesani, V., Charlier, J., Janssens, M., Delmee, M. (2004). Histidine Decarboxylase in Enterobacteriaceae Revisited. J. Clin. Microbiol. 42: 5923-5924 [Abstract] [Full Text]  
  • Lavigne, J.-P., Bouziges, N., Chanal, C., Mahamat, A., Michaux-Charachon, S., Sotto, A. (2004). Molecular Epidemiology of Enterobacteriaceae Isolates Producing Extended-Spectrum {beta}-Lactamases in a French Hospital. J. Clin. Microbiol. 42: 3805-3808 [Abstract] [Full Text]  
  • Chevalier, J., Bredin, J., Mahamoud, A., Mallea, M., Barbe, J., Pages, J.-M. (2004). Inhibitors of Antibiotic Efflux in Resistant Enterobacter aerogenes and Klebsiella pneumoniae Strains. Antimicrob. Agents Chemother. 48: 1043-1046 [Abstract] [Full Text]  
  • Marchandin, H., Godreuil, S., Darbas, H., Jean-Pierre, H., Jumas-Bilak, E., Chanal, C., Bonnet, R. (2003). Extended-Spectrum {beta}-Lactamase TEM-24 in an Aeromonas Clinical Strain: Acquisition from the Prevalent Enterobacter aerogenes Clone in France. Antimicrob. Agents Chemother. 47: 3994-3995 [Full Text]  
  • Arpin, C., Dubois, V., Coulange, L., Andre, C., Fischer, I., Noury, P., Grobost, F., Brochet, J.-P., Jullin, J., Dutilh, B., Larribet, G., Lagrange, I., Quentin, C. (2003). Extended-Spectrum {beta}-Lactamase-Producing Enterobacteriaceae in Community and Private Health Care Centers. Antimicrob. Agents Chemother. 47: 3506-3514 [Abstract] [Full Text]  
  • De Gheldre, Y., Avesani, V., Berhin, C., Delmee, M., Glupczynski, Y. (2003). Evaluation of Oxoid combination discs for detection of extended-spectrum {beta}-lactamases. J Antimicrob Chemother 52: 591-597 [Abstract] [Full Text]  
  • Gayet, S., Chollet, R., Molle, G., Pages, J.-M., Chevalier, J. (2003). Modification of Outer Membrane Protein Profile and Evidence Suggesting an Active Drug Pump in Enterobacter aerogenes Clinical Strains. Antimicrob. Agents Chemother. 47: 1555-1559 [Abstract] [Full Text]  
  • Dumarche, P., De Champs, C., Sirot, D., Chanal, C., Bonnet, R., Sirot, J. (2002). TEM Derivative-Producing Enterobacter aerogenes Strains: Dissemination of a Prevalent Clone. Antimicrob. Agents Chemother. 46: 1128-1131 [Abstract] [Full Text]  
  • Canton, R., Oliver, A., Coque, T. M., Varela, M. d. C., Perez-Diaz, J. C., Baquero, F. (2002). Epidemiology of Extended-Spectrum {beta}-Lactamase-Producing Enterobacter Isolates in a Spanish Hospital during a 12-Year Period. J. Clin. Microbiol. 40: 1237-1243 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»