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Journal of Clinical Microbiology, April 2001, p. 1586-1590, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1586-1590.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Persistence of a Distinct Corynebacterium diphtheriae Clonal Group within Two Communities in the United States and Canada Where Diphtheria Is Endemic

Chung K. Marston,^1,* Frances Jamieson,² Fred Cahoon,² Gail Lesiak,² Anne Golaz,³ Mike Reeves,¹ and Tanja Popovic¹

Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases,¹ and Epidemiology and Surveillance Division, National Immunization Program,³ Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, and Laboratory Services Branch, Ontario Ministry of Health, Toronto, Canada²

Received 12 July 2000/Returned for modification 26 September 2000/Accepted 13 January 2001

Molecular characterization of 53 U.S. and Canadian Corynebacterium diphtheriae isolates by multilocus enzyme electrophoresis, ribotyping, and random amplified polymorphic DNA showed that strains with distinct molecular subtypes have persisted in the United States and Canada for at least 25 years. These strains are endemic rather than imported from countries with current endemic or epidemic diphtheria.

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^* Corresponding author. Mailing address: Epidemic Investigations Laboratory, Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, CDC, MS G34, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-4057. Fax: (404) 639-3023. E-mail: CDK5{at}CDC.GOV.

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Journal of Clinical Microbiology, April 2001, p. 1586-1590, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1586-1590.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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