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Journal of Clinical Microbiology, April 2001, p. 1665-1668, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1665-1668.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Relevance of Reactivity in Commercially Available Hepatitis C Virus Antibody Assays

Susanne Polywka,* Matthias Schröter, Heinz-Hubert Feucht, Bernhard Zöllner, and Rainer Laufs

Institute for Medical Microbiology and Immunology, University Hospital Eppendorf, 20246 Hamburg, Germany

Received 7 September 2000/Returned for modification 21 November 2000/Accepted 23 January 2001

Sera from 2,148 patients were tested with a third-generation microparticle enzyme immunoassay (MEIA), a confirmatory assay, and a reverse transcription-PCR. Overall, 85.6% of reactivities were confirmed, 13.2% were shown to be unspecifically reactive, and 1.2% were indeterminate. The rate of confirmed MEIA reactivities clearly depended on the strength of the reactivity.

* Corresponding author. Mailing Address: Institute for Medical Microbiology and Immunology, University Hospital Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Phone: 49 40 42803 3147. Fax: 49 40 42803 4881. E-mail: polywka{at}uke.uni-hamburg.de.

Journal of Clinical Microbiology, April 2001, p. 1665-1668, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1665-1668.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2001 by the American Society for Microbiology. All rights reserved.