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Journal of Clinical Microbiology, May 2001, p. 1687-1690, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1687-1690.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Group A Streptococcal Genotypes from Pediatric Throat Isolates in Rome, Italy

Giordano Dicuonzo,1 Giovanni Gherardi,1 Giulia Lorino,2 Silvia Angeletti,1 Marina De Cesaris,1 Ersilia Fiscarelli,3 Debra E. Bessen,4 and Bernard Beall5,*

Department of Medicine and Microbiology, Università Campus Bio-Medico,1 Department of Microbiology, Università La Sapienza,2 and Laboratory of Microbiology, Pediatric Hospital "Bambin Gesù,"3 Rome, Italy; Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 065204; and Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 303335

Received 18 December 2000/Returned for modification 27 January 2001/Accepted 17 February 2001

In a study assessing genetic diversity, 114 group A streptococcus (GAS) isolates were recovered from pediatric pharyngitis patients in Rome, Italy. These isolates comprised 22 different M protein gene (emm) sequence types, 14 of which were associated with a distinct serum opacity factor/fibronectin binding protein gene (sof) sequence type. Isolates with the same emm gene sequence type generally shared a highly conserved chromosomal macrorestriction profile. In three instances, isolates with dissimilar macrorestriction profiles had identical emm types; in each of these cases multilocus sequence typing revealed that isolates with the same emm type were clones having the same allelic profiles. Ninety-eight percent of the pharyngeal isolates had emm types previously found to be highly associated with mga locus gene patterns commonly found in pharyngeal GAS isolates.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, Mailstop C02, 1600 Clifton Rd., NE, Atlanta, GA 30333. Phone: (404) 639-1237. Fax: (404) 639-3123. E-mail: BBeall{at}cdc.gov.

Journal of Clinical Microbiology, May 2001, p. 1687-1690, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1687-1690.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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