Journal of Clinical Microbiology, May 2001, p. 1687-1690, Vol. 39, No. 5
Department of Medicine and Microbiology,
Università Campus Bio-Medico,1
Department of Microbiology, Università La
Sapienza,2 and Laboratory of
Microbiology, Pediatric Hospital "Bambin
Gesù,"3 Rome, Italy; Department
of Epidemiology and Public Health, Yale University School of Medicine,
New Haven, Connecticut 065204; and
Respiratory Diseases Branch, Centers for Disease Control and
Prevention, Atlanta, Georgia 303335
Received 18 December 2000/Returned for modification 27 January
2001/Accepted 17 February 2001
In a study assessing genetic diversity, 114 group A streptococcus
(GAS) isolates were recovered from pediatric pharyngitis patients in
Rome, Italy. These isolates comprised 22 different M protein gene
(emm) sequence types, 14 of which were associated with a
distinct serum opacity factor/fibronectin binding protein gene
(sof) sequence type. Isolates with the same emm
gene sequence type generally shared a highly conserved chromosomal
macrorestriction profile. In three instances, isolates with dissimilar
macrorestriction profiles had identical emm types; in each
of these cases multilocus sequence typing revealed that isolates with
the same emm type were clones having the same allelic
profiles. Ninety-eight percent of the pharyngeal isolates had
emm types previously found to be highly associated with
mga locus gene patterns commonly found in pharyngeal GAS isolates.
0095-1137/01/$04.00+0 DOI: 10.1128/JCM.39.5.1687-1690.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Group A Streptococcal Genotypes from Pediatric
Throat Isolates in Rome, Italy
*
Corresponding author. Mailing address: Centers for
Disease Control and Prevention, Mailstop C02, 1600 Clifton Rd., NE,
Atlanta, GA 30333. Phone: (404) 639-1237. Fax: (404) 639-3123. E-mail: BBeall{at}cdc.gov.
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