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Journal of Clinical Microbiology, May 2001, p. 1960-1962, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1960-1962.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Utility of Paired BACTEC MYCO/F LYTIC Blood Culture Vials for Detection of Bacteremia, Mycobacteremia, and Fungemia

Lennox K. Archibald,1,* Hamish Dobbie,2,dagger Peter Kazembe,2 Okey Nwanyanwu,2,Dagger Celeste McKnight,3 Terry Byrne,3 Rachel M. Addison,3 Michael Bell,1 L. Barth Reller,3 and William R. Jarvis1

Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia1; Lilongwe Central Hospital, Lilongwe, Malawi2; and and Duke University Medical Center, Durham, North Carolina3

Received 16 November 2000/Returned for modification 14 January 2001/Accepted 20 February 2001

In previous bloodstream infection studies in Malawi, we inoculated blood from a single venesection into a single BACTEC MYCO/F LYTIC (MFL) vial. Inoculation of one vial, however, would be expected to reduce the sensitivity of bloodstream pathogen detection with MFL vials. To ascertain the degree of this loss of sensitivity, blood was drawn from each of 228 febrile, adult inpatients in Malawi and 5 ml of each blood sample was inoculated into each of two MFL vials. Of 228 paired vials, 51 (22%) were both positive, 172 (75%) were both negative, and 5 (3%) had discordant results. Bloodstream infection would have been detected in 11 (92%) of 12 patients with mycobacteremia and 38 (92%) of 41 patients with bacteremia had only one MFL vial been inoculated. Our study shows that a second MFL vial does not significantly increase diagnostic sensitivity.

* Corresponding author. Mailing address: Hospital Infections Program, Centers for Disease Control and Prevention, Mailstop A-35, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-6443. Fax: (404) 639-2647. E-mail: LCA6{at}CDC.GOV.

dagger Present address: Department of Renal Medicine, The Middlesex Hospital, Mortimer St., London W1N 8AA, United Kingdom.

Dagger Present address: Office of Health, Population & Nutrition, USAID/Mozambique, Maputo, Mozambique.

Journal of Clinical Microbiology, May 2001, p. 1960-1962, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1960-1962.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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