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Journal of Clinical Microbiology, May 2001, p. 1972-1974, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1972-1974.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of Sequence Analysis and the INNO-LiPA HBV DR Line Probe Assay for Detection of Lamivudine-Resistant Hepatitis B Virus Strains in Patients under Various Clinical Conditions

Stephan W. Aberle,1,* Josef Kletzmayr,2 Bruno Watschinger,2 Brigitte Schmied,3 Norbert Vetter,3 and Elisabeth Puchhammer-Stöckl1

Institute of Virology1 and Department of Medicine, Division of Nephrology and Dialysis,2 University of Vienna, and Pulmologisches Zentrum,3 Vienna, Austria

Received 13 October 2000/Returned for modification 4 January 2001/Accepted 5 March 2001

A line probe assay (INNO-LiPA HBV DR) detecting drug-resistant hepatitis B virus (HBV) strains was evaluated. Results concordant with sequence analysis were obtained with 48 of 56 serum samples from HBV-infected patients undergoing lamivudine therapy. In eight cases, additional minor subpopulations could be identified by the line probe assay.

* Corresponding author. Mailing address: Institute of Virology, University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria. Phone: 43 1 40490, ext. 79527. Fax: 43 1 406 21 61. E-mail: stephan.aberle{at}univie.ac.at.

Journal of Clinical Microbiology, May 2001, p. 1972-1974, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1972-1974.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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