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Journal of Clinical Microbiology, May 2001, p. 1978-1980, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1978-1980.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Evaluation of Clarithromycin Resistance and cagA and vacA Genotyping of Helicobacter pylori Strains from the West of Ireland Using Line Probe Assays

Kieran A. Ryan,1,2 Leen-Jan van Doorn,3 Anthony P. Moran,2 Maura Glennon,1 Terry Smith,1 and Majella Maher1,*

National Diagnostics Centre, BioResearch Ireland,1 and Department of Microbiology,2 National University of Ireland, Galway, Ireland, and Delft Diagnostics Laboratory, Delft, The Netherlands3

Received 20 November 2000/Returned for modification 27 January 2001/Accepted 17 February 2001

The prevalence of clarithromycin resistance-associated mutations, the cytotoxin-associated gene (cagA), and the various vacuolating cytotoxin (vacA) genotypes was determined in 50 gastric biopsy specimens from Helicobacter pylori-infected patients, using line probe assays. The clarithromycin resistance-associated mutation A2143G was detected in H. pylori strains from 26% of the specimens, which suggested that the high rate of H. pylori treatment failure in Ireland may be partly attributable to the presence of these mutations. All strains examined carried the vacA s1 genotype, and 76% were cagA positive. Of these 50 specimens, 13 (26%) carried H. pylori strains with vacA midregion genotype m1, 29 (58%) carried strains that were m2, 1 (2%) was infected by a strain that was positive for both m1 and m2, and 7 (14%) carried strains that could not be typed.

* Corresponding author. Mailing address: DNA Diagnostics Laboratory, The National Diagnostics Centre, BioResearch Ireland, National University of Ireland, Galway, Ireland. Phone: 35391-586559. Fax: 35391-586570. E-mail: Majella.Maher{at}nuigalway.ie.

Journal of Clinical Microbiology, May 2001, p. 1978-1980, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1978-1980.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.