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Journal of Clinical Microbiology, May 2001, p. 2009-2014, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.2009-2014.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Variable Oncogene Promoter Activity of Human Papillomavirus Type 16 Cervical Cancer Isolates from Australia

Kylie J. Watts, Carol H. Thompson, Yvonne E. Cossart, and Barbara R. Rose*

Department of Infectious Diseases, The University of Sydney, Sydney, New South Wales, Australia

Received 1 August 2000/Returned for modification 13 December 2000/Accepted 5 March 2001

The functional significance of sequence variation within the upstream regulatory region (URR) of six human papillomavirus type 16 (HPV16) cervical cancer isolates from Australia was investigated. Specific changes in transcription factor binding sites leading to increased promoter activity may explain the transforming ability of some episomal HPV16 isolates.

* Corresponding author. Mailing address: Department of Infectious Diseases, Blackburn Building (D06), The University of Sydney, Sydney, NSW 2006, Australia. Phone: 61 2 93512085. Fax: 61 2 93524731. E-mail: b_rose{at}infdis.usyd.edu.au.

Journal of Clinical Microbiology, May 2001, p. 2009-2014, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.2009-2014.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Syrjanen, S (2004). HPV infections and tonsillar carcinoma. J. Clin. Pathol. 57: 449-455 [Abstract] [Full Text]  


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