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Journal of Clinical Microbiology, June 2001, p. 2294-2297, Vol. 39, No. 6
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.6.2294-2297.2001

Biofilm Formation by Gram-Negative Bacteria on Central Venous Catheter Connectors: Effect of Conditioning Films in a Laboratory Model

R. Murga,* J. M. Miller, and R. M. Donlan

Biofilm Research Laboratory, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Received 29 November 2000/Returned for modification 7 March 2001/Accepted 29 March 2001

Human blood components have been shown to enhance biofilm formation by gram-positive bacteria. We investigated the effect of human blood on biofilm formation on the inner lumen of needleless central venous catheter connectors by several gram-negative bacteria, specifically Enterobacter cloacae, Pseudomonas aeruginosa, and Pantoea agglomerans. Results suggest that a conditioning film of blood components promotes biofilm formation by these organisms in an in vitro system.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, Mail Stop C-16, 1600 Clifton Rd. NE, Atlanta, GA 30333. Phone: (404) 639-2321. Fax: (404) 639-3822. E-mail: rmurga{at}cdc.gov.

Journal of Clinical Microbiology, June 2001, p. 2294-2297, Vol. 39, No. 6
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.6.2294-2297.2001


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