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Journal of Clinical Microbiology, June 2001, p. 2306-2307, Vol. 39, No. 6
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.6.2306-2307.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of a Polymer Conjugate-Enhanced Enzyme Immunoassay to Ligase Chain Reaction for Diagnosis of Chlamydia trachomatis in Endocervical Swabs

Max Chernesky,1,* Dan Jang,1 Debby Copes,2 Jay Patel,3 Astrid Petrich,1 Kathleen Biers,3 Arlene Sproston,3 and Julius Kapala3

McMaster University and St. Joseph's Hospital, Hamilton,1 Choice in Health Clinic, Toronto,2 and Gamma-Dynacare Medical Laboratories, Brampton,3 Ontario, Canada

Received 20 December 2000/Returned for modification 6 March 2001/Accepted 21 March 2001

Two endocervical swabs from each of 1,123 women were collected into manufacturer-supplied transport tubes and tested for Chlamydia trachomatis by a polymer conjugate-enhanced (PCE) enzyme immunoassay (EIA) (IDEIA PCE Chlamydia; DAKO) and a ligase chain reaction assay (LCx Chlamydia; Abbott). After confirmation by the EIA blocking test, the sensitivity of the IDEIA PCE remained at 91.8% and the specificity increased from 98.2 to 99.8% compared to LCx.

* Corresponding author. Mailing address: Medical Microbiology Service, St. Joseph's Hospital, 50 Charlton Ave. East, Room L424, Hamilton, Ontario L8N 4A6, Canada. Phone: (905) 521-6021. Fax: (905) 521-6083. E-mail: chernesk{at}mcmaster.ca.

Journal of Clinical Microbiology, June 2001, p. 2306-2307, Vol. 39, No. 6
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.6.2306-2307.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Fadel, S., Eley, A. (2008). Is lipopolysaccharide a factor in infectivity of Chlamydia trachomatis?. J Med Microbiol 57: 261-266 [Abstract] [Full Text]  
  • Horner, P., Skidmore, S., Herring, A., Sell, J., Paul, I., Caul, O., Egger, M., McCarthy, A., Sanford, E., Salisbury, C., MacLeod, J., Sterne, J., Low, N., for the Chlamydia Screening Studies (ClaSS) Group, (2005). Enhanced Enzyme Immunoassay with Negative-Gray-Zone Testing Compared to a Single Nucleic Acid Amplification Technique for Community-Based Chlamydial Screening of Men. J. Clin. Microbiol. 43: 2065-2069 [Abstract] [Full Text]  
  • Solomon, A. W., Peeling, R. W., Foster, A., Mabey, D. C. W. (2004). Diagnosis and Assessment of Trachoma. Clin. Microbiol. Rev. 17: 982-1011 [Abstract] [Full Text]  
  • Chernesky, M A (2002). Chlamydia trachomatis diagnostics. Sex. Transm. Infect. 78: 232-234 [Abstract] [Full Text]  


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