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Journal of Clinical Microbiology, June 2001, p. 2330-2334, Vol. 39, No. 6
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.6.2330-2334.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Characterization of IS6110 Restriction Fragment Length Polymorphism Patterns and Mechanisms of Antimicrobial Resistance for Multidrug-Resistant Isolates of Mycobacterium tuberculosis from a Major Reference Hospital in Assiut, Egypt

Said Abbadi,1 Heba G. Rashed,2 Glenn P. Morlock,1 Charles L. Woodley,1 O. El Shanawy,2 and Robert C. Cooksey1,*

Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 and Assiut University Hospital, Assiut, Egypt2

Received 13 December 2000/Returned for modification 10 February 2001/Accepted 21 March 2001

We evaluated 25 Mycobacterium tuberculosis isolates from patients at a major Egyptian reference hospital in Assiut, Egypt, who had been treated for at least 1 year for tuberculosis. Typing patterns (IS6110) were diverse, and multidrug resistance was found among 11 (44%) of the isolates. Mutations associated with antimicrobial drug resistance were found in rpoB, katG, rpsL, and embB in the resistant isolates.

* Corresponding author. Mailing address: Tuberculosis/Mycobacteriology Branch, Centers for Disease Control and Prevention, Mail Stop F-08, Atlanta, GA 30333. Phone: (404) 639-1283. Fax: (404) 639-1287. E-mail: rcc1{at}cdc.gov.

Journal of Clinical Microbiology, June 2001, p. 2330-2334, Vol. 39, No. 6
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.6.2330-2334.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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