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Journal of Clinical Microbiology, July 2001, p. 2565-2571, Vol. 39, No. 7
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.7.2565-2571.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nomenclature of Major Antimicrobial-Resistant Clones of Streptococcus pneumoniae Defined by the Pneumococcal Molecular Epidemiology Network

L. McGee,1,* L. McDougal,2 J. Zhou,3 B. G. Spratt,3 F. C. Tenover,2 R. George,4 R. Hakenbeck,5 W. Hryniewicz,6 J. C. Lefévre,7 A. Tomasz,8 and K. P. Klugman1

MRC/SAIMR/WITS Pneumococcal Diseases Research Unit, Johannesburg, South Africa1; Nosocomial Pathogens Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 303332; Department of Infectious Disease Epidemiology, Imperial College School of Medicine,3 and Respiratory and Systemic Infection Laboratory,4 London, England; University of Kaiserslautern, Kaiserslautern, Germany5; Sera and Vaccines Central Research Laboratory, Warsaw, Poland6; Laboratoire de Bactériologie, Toulouse, France7; and Rockefeller University, New York, New York 100218

Received 12 February 2001/Returned for modification 2 April 2001/Accepted 22 April 2001

The emergence of disease caused by penicillin-resistant and multidrug-resistant pneumococci has become a global concern, necessitating the identification of the epidemiological spread of such strains. The Pneumococcal Molecular Epidemiology Network was established in 1997 under the auspices of the International Union of Microbiological Societies with the aim of characterizing, standardizing, naming, and classifying antimicrobial agent-resistant pneumococcal clones. Here we describe the nomenclature for 16 pneumococcal clones that have contributed to the increase in antimicrobial resistance worldwide. Guidelines for the recognition of these clones using molecular typing procedures (pulsed-field gel electrophoresis, BOX-PCR, and multilocus sequence typing) are presented, as are the penicillin-binding profiles and macrolide resistance determinants for the 16 clones. This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, P.O. Box 1038, Johannesburg 2000, South Africa. Phone: 27 11 489-9335. Fax: 27 11 489-9332. E-mail: lesmcgee{at}hotmail.com.

Journal of Clinical Microbiology, July 2001, p. 2565-2571, Vol. 39, No. 7
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.7.2565-2571.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2001 by the American Society for Microbiology. All rights reserved.