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Journal of Clinical Microbiology, July 2001, p. 2590-2593, Vol. 39, No. 7
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.7.2590-2593.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Diagnosis of Bacteriuria by Detection of Volatile Organic Compounds in Urine Using an Automated Headspace Analyzer with Multiple Conducting Polymer Sensors

S. Aathithan,1 J. C. Plant,2 A. N. Chaudry,2 and G. L. French1,*

Department of Infection, Guy's, King's College and St. Thomas' School of Medicine, St. Thomas' Hospital, London SE1 7EH,1 and Osmetech plc, Electra House, Crewe CW1 6WZ,2 United Kingdom

Received 11 January 2001/Returned for modification 17 February 2001/Accepted 22 April 2001

The Osmetech Microbial Analyzer (OMA) is an automated headspace analyzer fitted with a novel detector system consisting of an array of polymer sensors, each of which responds to different volatile organic compounds. The system can be used for screening clinical urine specimens for significant bacteriuria by sampling urine headspace and subjecting the output of the multiple-detector response to principal component analysis. The OMA readily distinguished artificially infected urine samples from sterile controls. The OMA was then used to analyze 534 unselected clinical urine specimens, of which 21.5% had significant bacteriuria (containing >105 CFU of bacteria/ml). The sensitivity and specificity of the OMA compared with conventional culture were 83.5 and 87.6%, respectively. The OMA is a promising automated system for the rapid routine screening of urine specimens, and further clinical trials are in progress.

* Corresponding author. Mailing address: Department of Infection, King's College, St. Thomas' Campus, St. Thomas' Hospital, London SE1 7EH, United Kingdom. Phone: 44 (0) 207 928 9292, ext. 3244. Fax: 44 (0) 207 928 0730. E-mail: gary.french{at}kcl.ac.uk.

Journal of Clinical Microbiology, July 2001, p. 2590-2593, Vol. 39, No. 7
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.7.2590-2593.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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