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Journal of Clinical Microbiology, July 2001, p. 2719-2721, Vol. 39, No. 7
Departments of Pathology and Medicine,
Northwestern University Medical School,1 and
Divisions of Microbiology and Infectious Diseases,
Northwestern Memorial Hospital,2 Chicago,
Illinois 60611
Received 18 December 2000/Returned for modification 7 March
2001/Accepted 20 April 2001
The association between fluoroquinolone susceptibility
and DNA mutations coding for amino acid substitutions in the quinolone resistance-determining region was assessed with 44 clinical isolates of
Streptococcus pneumoniae. Twenty-three strains bore at
least one amino acid substitution. Only seven strains with
mutations were suggested by diminished susceptibility to
ciprofloxacin (MIC,
0095-1137/01/$04.00+0 DOI: 10.1128/JCM.39.7.2719-2721.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Fluoroquinolone Resistance Is a Poor Surrogate Marker for Type II
Topoisomerase Mutations in Clinical Isolates of
Streptococcus pneumoniae
2 µg/ml).
*
Corresponding author. Mailing address: Northwestern
Prevention Epicenter, Department of Pathology, Galter Carriage House, Room 701, Northwestern Memorial Hospital, 251-East Huron, Chicago, IL
60611. Phone: (312) 926-2885. Fax: (312) 926-4139. E-mail: lancer{at}northwestern.edu.
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