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Journal of Clinical Microbiology, August 2001, p. 2856-2859, Vol. 39, No. 8
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.8.2856-2859.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Quantitation of Varicella-Zoster Virus DNA in Patients with Ramsay Hunt Syndrome and Zoster Sine Herpete

Yasushi Furuta,1,* Fumio Ohtani,1 Hirofumi Sawa,2 Satoshi Fukuda,1 and Yukio Inuyama1

Department of Otolaryngology1 and Laboratory of Molecular & Cellular Pathology, CREST, JST,2 Hokkaido University School of Medicine, Sapporo, Japan

Received 13 February 2001/Returned for modification 7 April 2001/Accepted 11 June 2001

Varicella-zoster virus (VZV) reactivation causes facial nerve palsy in Ramsay Hunt syndrome (RHS) and zoster sine herpete (ZSH) with and without zoster rash, respectively. In the present study, we analyzed the VZV DNA copy number in saliva samples from 25 patients with RHS and 31 patients with ZSH using a TaqMan PCR assay to determine differences in the viral load between the two diseases. VZV copy number in saliva peaked near the day of the appearance of zoster in patients with RHS. Consequently, VZV DNA was less frequently detected in patients with RHS who exhibited facial palsy several days after the appearance of zoster. These findings suggest that the VZV load in saliva samples reflects the kinetics of viral reactivation in patients with RHS. In addition, VZV DNA was equally detected in saliva from patients with RHS and ZSH, and there was no significant difference in the highest viral copy number between patients with RHS and those with ZSH. The VZV load does not appear to reflect a major difference between RHS and ZSH.

* Corresponding author. Department of Otolaryngology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita-Ku, Sapporo 060-8638, Japan. Phone: 81-11-707-3387. Fax: 81-11-717-7566. E-mail: yfuruta{at}med.hokudai.ac.jp.

Journal of Clinical Microbiology, August 2001, p. 2856-2859, Vol. 39, No. 8
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.8.2856-2859.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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