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Journal of Clinical Microbiology, August 2001, p. 2946-2950, Vol. 39, No. 8
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.8.2946-2950.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Detection of Cervical Infections in Colposcopy Clinic Patients

Stuart Lanham,1,* Amanda Herbert,2 Adriana Basarab,3 and Peter Watt1

Department of Molecular Microbiology1 and Public Health Laboratory Service,3 Southampton General Hospital, Southampton SO16 6YD, and Histopathology Department, St. Thomas' Hospital, London SE1 7EH,2 United Kingdom

Received 20 November 2000/Returned for modification 24 January 2001/Accepted 30 May 2001

The purpose of this study was to determine if Neisseria gonorrhoeae; Chlamydia trachomatis; herpes simplex virus; cytomegalovirus; Epstein-Barr virus; human herpesviruses 6, 7, and 8; or adeno-associated virus influenced the production of cervical intraepithelial neoplasia. Two hundred thirty-one cervical smear samples were tested for the presence of the organisms by PCR. In addition, human papillomavirus types in the samples were determined by PCR and classified into cancer risk types of high, moderate, and low. There was no link with cervical intraepithelial neoplasia status and detection of herpes simplex virus, cytomegalovirus, Epstein-Barr virus, human herpesviruses 6 and 8, gonorrhea, or chlamydia. However, high-grade cervical intraepithelial neoplasia was found more frequently with mixed infection by moderate-risk human papillomavirus types and human herpesvirus 7 than with these papillomavirus types alone. The presence of human herpesvirus 7 may increase the oncogenic potential of moderate-risk human papillomavirus types.

* Corresponding author. Mailing address: HIT Group, Tenovus Laboratory, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom. Phone: 02380 796647. Fax: 02380 701416. E-mail: sal3{at}soton.ac.uk.

Journal of Clinical Microbiology, August 2001, p. 2946-2950, Vol. 39, No. 8
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.8.2946-2950.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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