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Journal of Clinical Microbiology, August 2001, p. 2954-2957, Vol. 39, No. 8
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.8.2954-2957.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Characterization of Borrelia burgdorferi Isolated from Erythema Migrans Lesions: Interrelationship of Three Molecular Typing Methods

Radha Iyer,1 Dionysios Liveris,1 Atoya Adams,1 John Nowakowski,2 Donna McKenna,2 Susan Bittker,2 Denise Cooper,2 Gary P. Wormser,2 and Ira Schwartz1,2,*

Department of Biochemistry & Molecular Biology1 and Division of Infectious Diseases, Department of Medicine,2 New York Medical College, Valhalla, New York 10595

Received 12 February 2001/Returned for modification 8 April 2001/Accepted 13 May 2001

Genetic diversity among Borrelia burgdorferi isolates recovered from the skin of Lyme disease patients was assessed by ribosomal DNA (rDNA) spacer restriction fragment length polymorphism analysis, genomic restriction site polymorphism analysis, and plasmid content analysis. There was a significant association between the three rDNA spacer types, the six pulsed-field gel types, and plasmid content (P < 0.001). The association between distinct chromosomal and plasmid markers implies a clonal origin for each genotype.

* Corresponding author. Mailing address: Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, NY 10595. Phone: (914) 594-4658. Fax: (914) 594-3455. E-mail: schwartz{at}nymc.edu.

Journal of Clinical Microbiology, August 2001, p. 2954-2957, Vol. 39, No. 8
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.8.2954-2957.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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