This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beard, P. M.
Right arrow Articles by Sharp, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beard, P. M.
Right arrow Articles by Sharp, J. M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, September 2001, p. 3080-3084, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3080-3084.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Experimental Paratuberculosis in Calves following Inoculation with a Rabbit Isolate of Mycobacterium avium subsp. paratuberculosis

P. M. Beard,1,dagger K. Stevenson,1 A. Pirie,1 K. Rudge,1 D. Buxton,1 S. M. Rhind,2 M. C. Sinclair,1 L. A. Wildblood,1 D. G. Jones,1 and J. M. Sharp1,*

Moredun Research Institute, International Research Centre, Pentlands Science Park,1 and Department of Veterinary Pathology, Easter Bush Veterinary Centre, University of Edinburgh,2 Bush Loan, Midlothian, Scotland EH26 0PZ, United Kingdom

Received 15 March 2001/Returned for modification 14 May 2001/Accepted 17 June 2001

The role of wildlife species in the epidemiology of paratuberculosis has been the subject of increased research efforts following the discovery of natural paratuberculosis in free-living rabbits from farms in east Scotland. This paper describes the experimental inoculation of young calves with an isolate of Mycobacterium avium subsp. paratuberculosis recovered from a free-living rabbit. After a 6-month incubation period, all eight calves inoculated with the rabbit isolate had developed histopathological and/or microbiological evidence of M. avium subsp. paratuberculosis infection. Similar results were obtained from a group of calves infected with a bovine isolate of M. avium subsp. paratuberculosis. The virulence of the rabbit isolate for calves demonstrated in this study suggests that rabbits are capable of passing paratuberculosis to domestic ruminants and that wildlife reservoirs of M. avium subsp. paratuberculosis should therefore be considered when formulating control plans for the disease.

* Corresponding author. Mailing address: Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, United Kingdom. Phone: 44 131 445 5111. Fax: 44 131 445 6111. E-mail: sharm{at}mri.sari.ac.uk.

dagger Present address: Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Journal of Clinical Microbiology, September 2001, p. 3080-3084, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3080-3084.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Judge, J., Kyriazakis, I., Greig, A., Davidson, R. S., Hutchings, M. R. (2006). Routes of Intraspecies Transmission of Mycobacterium avium subsp. paratuberculosis in Rabbits (Oryctolagus cuniculus): a Field Study. Appl. Environ. Microbiol. 72: 398-403 [Abstract] [Full Text]  
  • Judge, J., Kyriazakis, I., Greig, A., Allcroft, D. J., Hutchings, M. R. (2005). Clustering of Mycobacterium avium subsp. paratuberculosis in Rabbits and the Environment: How Hot Is a Hot Spot?. Appl. Environ. Microbiol. 71: 6033-6038 [Abstract] [Full Text]  
  • Waters, W. R., Miller, J. M., Palmer, M. V., Stabel, J. R., Jones, D. E., Koistinen, K. A., Steadham, E. M., Hamilton, M. J., Davis, W. C., Bannantine, J. P. (2003). Early Induction of Humoral and Cellular Immune Responses during Experimental Mycobacterium avium subsp. paratuberculosis Infection of Calves. Infect. Immun. 71: 5130-5138 [Abstract] [Full Text]  
  • Stratmann, J., Strommenger, B., Stevenson, K., Gerlach, G.-F. (2002). Development of a Peptide-Mediated Capture PCR for Detection of Mycobacterium avium subsp. paratuberculosis in Milk. J. Clin. Microbiol. 40: 4244-4250 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»