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Journal of Clinical Microbiology, September 2001, p. 3200-3203, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3200-3203.2001

Phylogenetic Origin of Hepatitis B Virus Strains with Precore C-1858 Variant

Erik Alestig, Charles Hannoun, Peter Horal, and Magnus Lindh*

Department of Clinical Virology, Göteborg University, Göteborg, Sweden

Received 19 January 2001/Accepted 13 July 2001

Mutations that prevent the expression of the hepatitis B e antigen frequently emerge in the immunoreactive phase of infection. The predominant mutation, the precore Gright-arrowA-1896 mutation, is restricted by the variability at position 1858 and is rare in strains with cytosine at nucleotide 1858. The C-1858 variant is characteristic of genotype A. It also occurs in genotypes C and F, but not in B, D, or E, explaining the geographical variation in the prevalence of precore mutants. C-1858 strains have been frequently observed in southeast Asia, but have not been phylogenetically characterized. By sequencing eight complete hepatitis B virus genomes, C-1858 variants of east Asian origin were found to constitute a phylogenetic entity within genotype C that probably diverged several hundred years ago. Further study of the distribution of this variant is warranted.

* Corresponding author. Mailing address: Department of Clinical Virology, Guldhedsgatan 10B, 413 46 Göteborg, Sweden. Phone: 46 31 3424976. Fax: 46 31 827032. E-mail: magnus.lindh{at}microbio.gu.se.

Journal of Clinical Microbiology, September 2001, p. 3200-3203, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3200-3203.2001


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